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Local Hyperthermia in Combination with Chemotherapeutic Agents

  • Chapter
Interstitial Hyperthermia

Abstract

It has been demonstrated that the cytotoxic effect of some chemotherapeutic agents is enhanced at elevated temperatures (Johnson and Pavelec, 1973, Hahn, 1978). As early as 1960 a clinical trial of combined hyperthermia and drug perfusions was performed on the patients with head and neck tumors (Woodhall et al, 1960). The combined use of hyperthermia and chemotherapeutic agents has been extensively studied since the early 1970s. Johnson and Pavelec (1973) demonstrated that the effect of an alkylating agent, thio-TEPA, on Chinese hamster fibroblasts was enhanced at elevated temperatures in vitro. The mechanism of this enhancement appeared to be due to an increased rate constant of alkylation at elevated temperatures. Hahn and his colleagues (1975) have demonstrated thermal enhancement of cytotoxicity of various agents and proposed additional mechanisms of thermal enhancement.

This study was partially supported by a grant CA26350 awarded by National Cancer Institute, DHHS.

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Authors and Affiliations

  1. Department of Radiation Medicine, University of Kentucky Medical Center, Kentucky, USA

    M. Urano & H. Majima

  2. Department of Radiation Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

    J. Kahn

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  1. M. Urano
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  2. J. Kahn
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  3. H. Majima
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Editors and Affiliations

  1. University Clinic of Radiotherapy, Vienna, Austria

    Leonore Handl-Zeller

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© 1992 Springer-Verlag/Wien

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Urano, M., Kahn, J., Majima, H. (1992). Local Hyperthermia in Combination with Chemotherapeutic Agents. In: Handl-Zeller, L. (eds) Interstitial Hyperthermia. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9155-2_3

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  • DOI: https://doi.org/10.1007/978-3-7091-9155-2_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9157-6

  • Online ISBN: 978-3-7091-9155-2

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