Mitochondrial energy crisis as a mechanism for nigral cell death

  • Y. Mizuno
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)


Studies on mitochondrial respiratory enzymes in Parkinson’s disease are reviewed. The presence of abnormalities in Complex I of the mitochondrial respiratory chain was described in Parkinson’s disease by several groups of investigators utilizing different methods. These abnormalities do not seem to be a primary defect of Parkinson’s disease. Instead, they seem to be a consequence of long-standing noxious stimuli to substantia nigra. Dopaminergic neurons in substantia nigra appear to have a unique property with reduced tolerance to various noxious stimuli. Further studies on mitochondria seem to be important for the elucidation of Parkinson’s disease.


Electron Transport System Mitochondrial Myopathy Mitochondrial Encephalomyopathy Mitochondrial Respiratory Enzyme Nigral Cell Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 1991

Authors and Affiliations

  • Y. Mizuno
    • 1
  1. 1.Department of NeurologyJuntendo University School of MedicineBunkyo, Tokyo 113Japan

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