Positron emission tomographic study in Parkinson’s disease—rigid vs tremor type
Using 15O (O2, CO2) and 18F-fluoro-deoxyglucose, a positron emission tomographic study was carried out to elucidate ongoing changes in a whole brain in cases with rigid- and tremor-type Parkinson’s disease (PA), respectively. For comparison, cases with essential tremor and normal control were also examined. MRI and XCT images and depth recording from basal ganglia during the course of stereotactic thalamotomy were considered together.
In rigid-type PA, cortical rCBF, rCMRO2 and rCMRGl were significantly reduced. However, 18FDG in basal ganglia (especially in the region of putamen and pallidum) was maintained in the normal or even in higher level. Microrecording also revealed reduced electrical activity in caudate nucleus, in contrast with higher activity in pallidum.
In tremor-type PA, the reduction of cortical metabolic rate was moderate, and activity in the caudate was maintained.
Metabolic rate in essential tremor and normal case seemed to be similar: it was high in cortical level and basasl ganglia (Cd was more active than putamen-pallidum).
Different metabolic features between rigid- and tremor- type PA were emphasized.
KeywordsPositron Emission Tomography Essential Tremor Positron Emission Tomography Study Cerebral Metabolic Rate Depth Recording
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- Brooks DJ, Frackowiak RSJ (1989) PET and movement disorders. J Neurol Neurosurg Psychiatry [Special Suppl]: 68–77Google Scholar
- Eidelberg D, Moeller JR, Dhawan V, Sidtis JJ, Ginos JZ, Strother SC, Cedarbaum J, Greene P, Fahn S, Rottenberg DA (1990) The metabolic anatomy of Parkinson’s disease: complementary [18F] fluorodeoxyglucose and [18F] fluoro-dopa positron emission tomographic studies. Movement Disorders 5: 203–213PubMedCrossRefGoogle Scholar
- Hirato M, Kawashima Y, Shibazaki T, Shibasaki T, Ohye C (1989) Pathophysiology of parkinsonian rigidity (japanese). Functional Neurosurg 28: 1–9Google Scholar
- Ohye C (1985) Studies on the functional disorders of the brain by PET scan (japanese). Proc 17th Japan Conference on Radiation and Radioisotopes, pp 127–132Google Scholar
- Ohye C (1988) Selective thalamotomy for movement disorders: microrecording stimulation, techniques and results. In: Lunsford LD (ed) Modern stereotactic surgery. Martius Nijhoff, Boston, pp 315–331Google Scholar
- Ohye C (1989) A new aspect of parkinsonian tremor and rigidity (japanese). Internal Med 63: 831–836Google Scholar
- Ohye C (1990) Regional cerebral metabolism in movement disorders (japanese). In: Nagatsu T, et al (eds) Receptors of the brain and movement. Heibonsha, Tokyo, pp 135–145Google Scholar
- Ohye C, Shibazaki T, Hirato M, Kawashima Y, Matsumura M, Shibasaki T (1990) Neural activity of the basal ganglia in Parkinson’s disease studied by depth recording and PET scan. In: Bernardi (ed) Basal Ganglia III. Plenum, New York London, pp 637 – 644Google Scholar
- Shibasaki T (1984) Analysis of human cerebral functions using positron emission tomography (PET) — A review (japanese). Progr Neurosci 28:211 — 228Google Scholar
- Shibasaki T (1989) Cerebral functions evaluated by blood flow studies in normal andpathological states (japanese). Neurosci Rev 3:150–178Google Scholar
- Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M, (1977) the [14C]desoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28: 897–916.PubMedCrossRefGoogle Scholar