Topics of special interest in research of Parkinson’s disease

  • H. Narabayashi
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)


Parkinson’s disease (PD) has been recognized as a idiopathic, degenerating disease presenting a mixture of a variety of different grades of rigidity, tremor, and akinesia. Today it is established that the axial pathology of the disease is the nigrostriatal DA deficiency, for which the treatment using levodopa or DA agonists produces markedly favourable results. Due to advances in drug treatment and resulting prolongation of the life span of PD patients, symptoms that had previously been not considered as being of core importance, have slowly become recognized as being important. These symptoms and difficulties in the later stage of the patients under long-term levodopa treatment for more than several years are disturbances of postural control and gait, emotional deterioration, and deterioration of cognitive function.


Locus Ceruleus Emotional Deterioration Stereotaxic Surgery Molecular Biological Investigation MPTP Monkey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Forno LS, Langston JW, DeLanney LE, Irwin I (1988) An electron microscopic study of MPTP-induced inclusion bodies in an old monkey. Brain Res 448: 150–157PubMedCrossRefGoogle Scholar
  2. Nakamura R, Narabayashi H (1976) Arrhythmokinesia in parkinsonism. In: Birkmayer W, Hornykiewicz O (eds) Advances in parkinsonism. Roche, Basle, pp 258–268Google Scholar
  3. Narabayashi H (1990a) Surgical treatment in the levodopa era. In: Stern G (ed) Parkinson’s disease. Chapman & Hall, London, pp 597–646Google Scholar
  4. Narabayashi H (1990b) Clinical analysis of juvenile and classical parkinsonism and underlying pathophysiological mechanism. Presented at the XIth International Congress of Neuropathology, Kyoto, 1990Google Scholar

Copyright information

© Springer-Verlag/Wien 1991

Authors and Affiliations

  • H. Narabayashi
    • 1
  1. 1.Juntendo UniversityTokyoJapan

Personalised recommendations