Epidemiology of Parkinson’s disease-interplaying genes and environmental factors
Epidemiology is one of the methods for solving a complex interplay of genes and environmental factors in Parkinson’s disease (PD).
A multifactorial inheritance has been proposed. Low concordance in twins refuted the role of genes in PD, but the small sample size did not allow a final conclusion. This author pooled twin and sib data from various sources and obtained 65% as the heritability of PD.
Risk factors are of importance in resolving the interplay. Well-accepted factors are age, smoking, preclinical personality profiles, and affection of the relatives with PD. We evaluated 271 questions in 166 cases along with two each of controls. PD-prone lifestyles were: 1) non-Japanese diet; 2) less smoking 3) less drinking; 4) fewer hobbies and if any, indoor hobbies requiring no partner; 5) interested only in business, narrow surroundings, etc.; 6) more habitual constipation, less circulatory disease; 7) less physical exercise; and 8) preclinical personality.
PD is probably a consequence of a long-standing age-dependent process modified by the interaction of a genetic predisposition and cumulated effects of numerous neurotoxins exposed for decades of time.
KeywordsMotor Neuron Disease None None Dizygotic Twin Xeroderma Pigmentosum Circulatory Disease
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