Association of Xba I allele (Xba I 44kb) of the human cytochrome P-450dbI (CYP2D6) gene in Japanese patients with idiopathic Parkinson’s disease
Cytochrome P-450dbl gene (CYP2D6) Xba I genotypes were investigated in 43 unrelated healthy Japanese and 51 patients with idiopathic Parkinson’s disease (IPD), using genomic DNA hybridization analysis with a cDNA probe encoding cytochrome P- 450dbl. Restriction fragment length polymorphisms (RFLPs) were observed in both populations, but the frequencies of alleles detected by restriction enzyme Xba I differed significantly. The relative risk of IPD is 2.15 times greater for idividuals with a Xba I 44 kb allele compared to those without the allele (x2 = 4.149, d.f. = 1, p < 0.05). Furthermore, the relative risk of IPD is 6.32 times greater for the Xba I 44 kb homozygotes than the Xba I 29 kb homozygotes (x2 = 4.935, d.f. = 1, p < 0.05). These data suggest that the Xba I 44 kb allele of CYP2D6 is one of the genetic factors making humans susceptible to IPD acquisition.
KeywordsExtensive Metabolizer Restriction Fragment Length Polymorph CYP2D6 Genotype Restriction Fragment Length Poly Defective Allele
Unable to display preview. Download preview PDF.
- Barbeau A, Cloutier T, Roy M, Plasse L, Paris S, Poirier J (1985) Ecogenetics of Parkinson’s disease: 4-hydroxylation of debrisoquine. Lancet ii: 1213–1215Google Scholar
- Barbeau A, Roy M, Cloutier T, Plasse L, Paris S (1986) Environmental and genetic factors in the etiology of Parkinson’s disease. Adv Neurol 45: 299–306Google Scholar
- Mahgoub A, Idle JR, Dring LG, Lancaster R, Smith RL (1977) Polymorphic hydroxylation of debrisoquine in man. Lancet ii: 584–586Google Scholar
- Niznik HB, Tyndale RF, Sallee FR, Gonzalez FJ, Hardwick JP, Inaba T, Kalow W (1990) The dopanime transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain; resolution and identification of two distinct [3H]-GBR- 12935 binding proteins. Arch Biochem Biophys 276: 424–432PubMedCrossRefGoogle Scholar
- Yue QY, Bertilsson L, Dahl-Puustinen ML, Sawe J, Sjogvist F, Johansson I, Ingelman- Sundberg M (1989) Dissassociation between debrisoquine hydroxylation phenotype and genotype among Chinese. Lancet ii: 870Google Scholar