Cytoskeleton pathology in Alzheimer’s disease and related disorders

  • F. Seitelberger
  • H. Lassmann
  • C. Bancher
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 33)


The reported findings suggest that ubiquitination of pathological proteinaceous intracytoplasmic inclusions is not at all specific of AD. On the contrary it appears to be a general biochemical marker for disorders in the degradation of a variety of cytoskeletal and other cytoplasmic proteins. The pattern of affected cytoskeletal components is not specific of AD/SDAT tangles. Tau definitely is present also in PSP tangles and possibly in Pick bodies but not in Lewy bodies.

Therefore it has to be considered that the intracytoplasmic accumulation of cytoskeletal protein/ubiquitin complexes in itself is a rather unspecific cellular reaction pattern, possibly a secondary reaction to cell injury of many types, especially, however, of neuronal aging. Nevertheless, the manifestation of NFT in an excessive quantity, intensity, and dynamics with severe concomitant lesions as in AD/SDAT undoubtedly is a true pathological and in this sense a disease-specific change.


Lewy Body Progressive Supranuclear Palsy Neurofibrillary Tangle Progressive Supranuclear Palsy Antigenic Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • F. Seitelberger
    • 1
    • 2
  • H. Lassmann
    • 1
  • C. Bancher
    • 1
  1. 1.Institut für Hirnforschung der Österreichischen Akademie der Wissenschaften and Neurologisches InstitutUniversität WienViennaAustria
  2. 2.Neurologisches Institut der UniversitätWienAustria

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