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Extrapyramidal disturbances after cyanide poisoning (first MRT-investigation of the brain)

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Age-associated Neurological Diseases

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 33))

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Summary

A 29 year old student of chemistry took 50 ml of a 1% potassium cyanide solution (500 mg) in attempted suicide. He became comatose, mydriatic and was admitted to hospital in an apneic state. He woke up after seven hours and developed Parkinsonism in the following weeks. This regressed slowly in the second month after the poisoning apart from dysarthria, bradykinesia of the upper limbs and very brisk monosynaptic reflexes. Three weeks after the intoxication, CCT was largely normal, and there was CSF-dense hypodensity in both putamina after five months. Sharply delimited signal elevation in T2 corresponding to the two putamina was detected in the MRI eight weeks and five months after ingestion of the poison.

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References

  • Aquilonius SM, Asmark H, Enoksson P, Lundberg PO, Moström U (1978) Computerized tomography in serve methanol intoxication. Br Med J 2: 929–930

    Article  PubMed  CAS  Google Scholar 

  • Aquilonius SM, Bergström K, Enoksson P, Hedstrand U, Lundberg PO, Moström U, Olsson Y (1980) Cerebral computer tomography in methanol intoxication. J Comput Assist Tomogr 4: 425–428

    Article  PubMed  CAS  Google Scholar 

  • Braico KT, Humbert JR, Terplan K, Lehotay JM (1979) Laetrile intoxication. Report of a fatal case. N Engl J Med 300: 238–240

    Article  PubMed  CAS  Google Scholar 

  • Brierley JJB (1975) A comparison between the effects of profound hypotension, hypoxia and cyanide to the brain of M. Mulatta in primate models of neurological disorders. In: Meldrum BS (ed) Raven Press, New York, pp 116–128

    Google Scholar 

  • Destee A, Courteville V, Devos PH, Besson P, Warot P (1985) Computing tomography and acute carbon monoxide poisoning. J Neurol Neurosurg Psychiatry 48: 281–282

    Article  PubMed  CAS  Google Scholar 

  • Edelmann F (1921) Ein Beitrag zur Vergiftung mit gasförmiger Blausäure, insbesondere zu den dabei auftretenden Gehirnveränderungen. Dtsch Z Nervenheilkd 72: 259–287

    Article  Google Scholar 

  • Ferraro (1933) cit. from Hurst 1940

    Google Scholar 

  • Finelli PF (1981) Case report changes in the basal ganglia following cyanide poisoning. J Comput Assist Tomogr 5: 775–756

    Article  Google Scholar 

  • Funata N, Song S-Y, Okeda R, Funata M, Higashino F (1984) A study of experimental cyanide encephalopathy in the acute phase-physiological and neuropathological correlation. Acta Neuropathol 107: 64–99

    Google Scholar 

  • Haymaker W, Ginzler AM, Ferguson RL (1952) Residual neuropathological effects at cyanide poisoning: a study of the central nervous system of 23 dogs exposed to cyanide compounds. Milit Surg 111: 231–246

    CAS  Google Scholar 

  • Hicks (1940) cit from Hurst 1940

    Google Scholar 

  • Hurst EW (1940) Experimental demyelination of the central nervous system. I. The encephalopathy by potassium cyanide. Aust J Exp Biol Med Sci 18: 201–223

    Article  CAS  Google Scholar 

  • Jacobs K (1984) Erfahrungsbericht über die Anwendung von 4DMAP bei schwerer Blausäurevergiftung. Konsequenzen für die Praxis. Zentralbi Arbeitsmed 34: 274–277

    CAS  Google Scholar 

  • Jaeckle RS, Nasrallah HA (1985) Major depression and carbon monoxide-induced parkinsonism: diagnosis, computerized axial tomography and response to L-Dopa. J Nerv Ment Dis 173: 503–508

    Article  PubMed  CAS  Google Scholar 

  • Kim YH, Foo M, Terry RD (1982) Cyanide encephalopathy following therapy with sodium nitroprusside. Arch Pathol Lab Med 106: 392–393

    PubMed  CAS  Google Scholar 

  • McLean DR, Jacobs H, Mielke BW (1980) Methanol poisoning. A clinical and pathological study. Ann Neurol 8: 161–167

    Article  PubMed  CAS  Google Scholar 

  • Messing B, Storch B (1988) Computer tomography and magnetic resonance imaging in cyanide poisoning. Eur Arch Psychiatr Neurol Sci 237: 139–143

    Article  CAS  Google Scholar 

  • Meyer A (1933) Experimentelle Vergiftungsstudien. III. Ãœber Gehirnveränderungen bei experimenteller Blausäurevergiftung. Z Ges Neurol Psychiatr 143: 333–348

    Article  Google Scholar 

  • Pentschew A (1958) Blausäurevergiftung. In: Lubarsch VO, Henke F, Rössle R (Hrsg) Handbuch der speziellen Pathologischen Anatomie und Histologie, Bd Nervensystem, 2. Teil, Bandteil B. Springer, Berlin Göttingen Heidelberg, 13. 2149–2156

    Google Scholar 

  • Sawada Y, Takahashi M, Ohashi N (1980) Computerized tomography as an indication of long term outcome after acute carbon monoxide poisoning. Lancet 1: 783–784

    PubMed  CAS  Google Scholar 

  • Schmorl G (1920) Gehirn bei Blausäurevergiftung. Munch Med Wochenschr 67: 913

    Google Scholar 

  • Uitti RJ, Rajput AH, Ashenhurst EM, Rozdilsky B (1985) Cyanide-induced parkinsonism: a clinico-pathologic report. Neurology 35: 921–925

    PubMed  CAS  Google Scholar 

  • Ule G, Pribilla O (1962) Hirnveränderungen nach Cyankalivergiftung mit protrahiertem (intervallären) klinischen Verlauf. Acta Neuropathol (Berlin) 1: 406–410

    Article  Google Scholar 

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© 1991 Springer-Verlag

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Messing, B. (1991). Extrapyramidal disturbances after cyanide poisoning (first MRT-investigation of the brain). In: Deecke, L., Dal-Bianco, P. (eds) Age-associated Neurological Diseases. Journal of Neural Transmission, vol 33. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9135-4_22

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  • DOI: https://doi.org/10.1007/978-3-7091-9135-4_22

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82261-6

  • Online ISBN: 978-3-7091-9135-4

  • eBook Packages: Springer Book Archive

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