Summary
13 patients with PD of recent onset underwent a series of neuropsychological tests for frontal lobe associated functions (Sternberg paradigm, WCST, CVLT) before and during treatment with Artane.® Test results at baseline were not significantly different from those of an age-matched control group (n = 13). Retesting after a mean of 2 weeks’ treatment with trihexyphenidyl revealed only slight impairment in CVLT while performance on the other tests remained unchanged.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Atkinson RC, Shiffrin RM (1971) The control of short-term memory. Scientific American Offprint 538: 1–11
Bowen FP, Kamienny RS, Burns MM, Yahr MD (1975) Parkinsonism: effects of levo-dopa treatment on concept formation. Neurology 25: 701–704
Delis DC, Kramer J, Ober BA, Kaplan E (1986) The California verbal learning test: administration and interpretation. Preliminary Manual
Drachman DA (1977) Memory and cognitive function in man: does the cholinergic system have a specific role? Neurology 27: 783–790
Dubois B, Danzé F, Pillon B, Cusimano G, Lhermitte F, Agid Y (1987) Cholinergic-dependent cognitive deficits in Parkinson’s disease. Ann Neurol 22: 26–30
Gibb WRG (1989) Dementia and Parkinson’s disease. Br J Psychiatry 154: 596–614
Gotham AM, Brown RG, Marsden CD (1988) “Frontal” cognitive function in patients with Parkinson’s disease “on” and “off” levodopa. Brain 111: 299–321
Hakim AM, Mathieson G (1979) Dementia in Parkinson’s disease: a neuopathological study. Neurology 29: 1209–1214
Heaton RK (1980) Wisconsin card sorting test manual. Psychological Assessment Resources, Inc
Karamat E, Ilmberger J, Poewe W, Gerstenbrandt F (1990) Memory dysfunction in Parkinson patients: an analysis of cerebral learning processes (this volume)
Koller WC (1984) Disturbance of recent memory function in parkinsonian patients on anticholinergic therapy. Cortex 20: 307–311
Kopelman MD (1986) The cholinergic neurotransmitter system in human memory and dementia: a review. Quart J Exp Psychol 38A: 535–573
Lees, AJ, Smith E (1983) Cognitive deficits in the early stages of Parkinson’s disease. Brain 106: 257–270
Lezak MD (1983) Memory functions. In: Lezak MD (ed) Neuropsychological assessment. Oxford University Press, New York Oxford, pp 414–467
McEvoy JP, McCue M, Spring B, Mohs RC, Lavori PW, Farr RM (1987) Effects of amantadine and Trihexiphenidyl on memory in elderly normal volunteers. Am J Psychiatry 144: 573–577
Miller E, Berrios GE, Politynsa B (1987) The adverse effect of benzhexol on memory in Parkinson’s disease. Acta Neurol Scand 76: 278–282
Pope DM (1987) The California verbal learning test: performance of normal adults aged 55–91 (unpublished)
Rogers D (1986) Bradyphrenia in parkinsonism: a historical review. Psych Med 16: 257–265
Rogers D, Lees AJ, Smith E, Trimble M, Stern GM (1987) Bradyphrenia in Parkinson’s disease and psychomotor retardation in depressive illness. Brain 110: 761–776
Sadeh M, Braham J, Modan M (1982) Effects of anticholinergic drugs on memory in Parkinson’s disease. Arch Neurol 39: 666–667
Starkstein SE, Leiguarda R, Gershanik O, Berthier M (1987) Neuropsychological disturbances in hemi-Parkinson’s disease. Neurology 37: 1762–1764
Sternberg S (1966) High-speed scanning in human memory. Science 153: 652–654
Taylor AE, Saint-Cyr JA, Lang AE (1986) Frontal lobe dysfunction in Parkinson’s disease. Brain 109: 845–883
Whitehouse, PJ, Martino AM, Marcus KA, Zweig RM, Singer HS, Price DL, Kellar KJ (1988) Reductions in acetylcholine and nicotine binding in several degenerative diseases. Arch Neurol 45: 722–724
Wilson RS, Kaszniak AW, Klawans HL, Garron DC (1980) High speed memory scanning in Parkinsonism. Cortex 16: 67–72
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag
About this chapter
Cite this chapter
Schelosky, L., Benke, T., Poewe, W.H. (1991). Effects of treatment with trihexyphenidyl on cognitive function in early Parkinson’s disease. In: Deecke, L., Dal-Bianco, P. (eds) Age-associated Neurological Diseases. Journal of Neural Transmission, vol 33. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9135-4_20
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9135-4_20
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82261-6
Online ISBN: 978-3-7091-9135-4
eBook Packages: Springer Book Archive