Effects of treatment with trihexyphenidyl on cognitive function in early Parkinson’s disease

  • L. Schelosky
  • Th. Benke
  • W. H. Poewe
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 33)


13 patients with PD of recent onset underwent a series of neuropsychological tests for frontal lobe associated functions (Sternberg paradigm, WCST, CVLT) before and during treatment with Artane.® Test results at baseline were not significantly different from those of an age-matched control group (n = 13). Retesting after a mean of 2 weeks’ treatment with trihexyphenidyl revealed only slight impairment in CVLT while performance on the other tests remained unchanged.


Free Recall Digit Span Digit Symbol Parkinsonian Patient Wisconsin Card Sort Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • L. Schelosky
    • 1
  • Th. Benke
    • 2
  • W. H. Poewe
    • 3
  1. 1.Department of NeurologyUKRVBerlinFederal Republic of Germany
  2. 2.University Clinic for NeurologyInnsbruckAustria
  3. 3.Department of NeurologyUKRVBerlin 19Federal Republic of Germany

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