Pattern electroretinogram and luminance electroretinogram in Alzheimer’s disease
Visual symptoms are often among the first complaints of patients suffering from Alzheimer’s disease and several studies showed a delay in flash visual evoked potentials. Hinton et al. (1986) described optic nerve degenerations in patients with Alzheimer’s disease and Sadun published a dropout of retinal ganglion cells that range from 30% to 60%. The reduction of neurotransmitters, especially of acetylcholin, found in the brain might also occure in the retina. Therefore we examined the retinal functions of patients suffering from Alzheimer’s disease.
In eight patients the pattern-electroretinograms and the scotopic and photopic luminance-electroretinograms were recorded and compared to an age-matched control group. We could not find any abnormalities in the pattern- and the luminance electroretinograms of patients with Alzheimer’s disease. Although cholinergic cells have been found in the retina, our results did not reveal an involvement of retinal functions in Morbus Alzheimer.
KeywordsRetinal Ganglion Cell Retinal Function Cholinergic Cell Pattern Electroretinogram Presenile Dementia
Unable to display preview. Download preview PDF.
- Orwin A, Wright CE, Harding GF, Rowan DC, Rolfe EB (1986) Serial visual evoked potential recording in Alzheimer’s disease. Br Med J: 293Google Scholar
- Rossor M (1987) Cerebral aging. Eye 1: 171–174Google Scholar
- Sadun A, Borchert M, DeVita E, Hinton D, Bassi CJ (1987) Assessment of visual impairment in patients with Alzheimer’s disease. Am J Ophtalmol 104: 113–120Google Scholar
- Visser SL, Stam FC, Van Tilburg W, op den Velde W, Blom JL, de Rijke W (1976) Visual evoked response in senile and presenile dementia. Electroencephalogr Clin Neurophysiol 40: 385–392Google Scholar
- de Vries-Khoe LH, Spekreijse H (1982) Maturation of luminance and pattern EPs in man. Doc Ophtalmol Proc Series 31: 461–475Google Scholar