Autoradiographic Patterns of Brain Interstitial Fluid Flow After Collagenase-induced Haemorrhage in Rat
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Cerebral oedema accompanies intracerebral haemorrhage. We induced intracranial bleeding by the intracerebral injection of bacterial collagenase. There was oedema observed both at the haematoma site in the caudate/putamen and bilaterally in the hippocampal regions. To determine the role of vasogenic oedema spread from the site of injury, we studied by autoradiography the distribution of extracellular markers injected along with the collagenase. Both 14 Cdextran (m.w. 70,000) and 14 C-sucrose (m.w. 341) spread away from the injection site into both hippocampal regions in a similar pattern, suggesting bulk flow. Vasogenic oedema secondary to a haemorrhagic lesion in the caudate/putamen is an important cause of the oedema observed in both hippocampal regions in our model.
KeywordsIntracerebral Haemorrhage Bulk Flow Vasogenic Oedema Perivascular Space Hippocampal Region
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- 2.Fenstermacher JD, Patlak CS (1976) The movements of water and solutes in the brains of mammals. In: Pappius HM, Feindel W (eds) The dynamics of brain oedema. Springer, New YorkGoogle Scholar
- 4.Rennels ML, Gregory TF, Blaumanis OR, Fujimoto K, Grady PA (1985) Evidence for a “paravascular” fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res 326: 47–63PubMedCrossRefGoogle Scholar
- 8.Rosenberg GA, Kyner WT, Estrada E (1980) Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions. Am J Physiol 238: 42–49Google Scholar
- 12.Zulch KJ (1971) Haemorrhage, thrombosis, embolism. In: Minckler J (ed) Pathology of the nervous system. McGraw-Hill Book Corp, New YorkGoogle Scholar