Autoradiographic Patterns of Brain Interstitial Fluid Flow After Collagenase-induced Haemorrhage in Rat

Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


Cerebral oedema accompanies intracerebral haemorrhage. We induced intracranial bleeding by the intracerebral injection of bacterial collagenase. There was oedema observed both at the haematoma site in the caudate/putamen and bilaterally in the hippocampal regions. To determine the role of vasogenic oedema spread from the site of injury, we studied by autoradiography the distribution of extracellular markers injected along with the collagenase. Both 14 Cdextran (m.w. 70,000) and 14 C-sucrose (m.w. 341) spread away from the injection site into both hippocampal regions in a similar pattern, suggesting bulk flow. Vasogenic oedema secondary to a haemorrhagic lesion in the caudate/putamen is an important cause of the oedema observed in both hippocampal regions in our model.


Intracerebral Haemorrhage Bulk Flow Vasogenic Oedema Perivascular Space Hippocampal Region 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  1. 1.Departments of Neurology, Physiology, and Mathematics and StatisticsUniversity of New MexicoUSA
  2. 2.Neurology and Research ServicesVeterans Affairs Medical CenterAlbuquerqueUSA

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