Changes in Extracellular Glutamate Concentration After Acute Subdural Haematoma in the Rat — Evidence for an “Excitotoxic” Mechanism?

  • R. Bullock
  • S. Butcher
  • J. McCulloch
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


Using a rat model of subdural haematoma which is associated with ischaemic damage in the ipsilateral hemisphere, we have measured cerebral blood flow and release of excitatory amino acids after the haematoma. A more than sevenfold rise in glutamate and aspartate, persisting for forty minutes occurred in the severely ischaemic cortex (CBF < 5 ml 100 gm−1 min−1) and a threefold, sustained rise was seen in hippocampus, although CBF was preserved (85 ml/100 g/−1 min−1). Excitotoxic mechanisms may, therefore, be involved in the ischaemic damage associated with subdural haematoma.


Cerebral Blood Flow Excitatory Amino Acid Subdural Haematoma Ipsilateral Hemisphere Ischaemic Damage 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. Bullock
    • 1
  • S. Butcher
  • J. McCulloch
  1. 1.University Department of Neurosurgery, Institute of Neurological SciencesSouthern General HospitalGlasgowScotland

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