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Changes in Extracellular Glutamate Concentration After Acute Subdural Haematoma in the Rat — Evidence for an “Excitotoxic” Mechanism?

  • R. Bullock
  • S. Butcher
  • J. McCulloch
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

Using a rat model of subdural haematoma which is associated with ischaemic damage in the ipsilateral hemisphere, we have measured cerebral blood flow and release of excitatory amino acids after the haematoma. A more than sevenfold rise in glutamate and aspartate, persisting for forty minutes occurred in the severely ischaemic cortex (CBF < 5 ml 100 gm−1 min−1) and a threefold, sustained rise was seen in hippocampus, although CBF was preserved (85 ml/100 g/−1 min−1). Excitotoxic mechanisms may, therefore, be involved in the ischaemic damage associated with subdural haematoma.

Keywords

Cerebral Blood Flow Excitatory Amino Acid Subdural Haematoma Ipsilateral Hemisphere Ischaemic Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bullock R, McCulloch J, Graham DI et al (1990) Focal ischaemic damage is reduced by CPP-ene — Studies in two animal models. Stroke (in press)Google Scholar
  2. 2.
    Bullock R, Teasdale G (1989) Surgical management of traumatic intracranial haematomas. In: Braakman (ed) Handbook of clinical neurology. Head injury, Vol 24 (in press)Google Scholar
  3. 3.
    Butcher SP, Bullock R, Graham DI et al (1990) Occlusion of the middle cerebral artery induces release of neuro-active amino acids in rat striatum and cortex: Correlation with neuropathological outcome. In: Proc. of 3rd International Symposium on the pharmacology of cerebral ischaemia. Marburg, Germany (in press)Google Scholar
  4. 4.
    Graham DI, Adams JH, Doyle D (1968) Ischaemic brain damage in fatal non-missile head injuries. J Neurol Sci 39: 213–234CrossRefGoogle Scholar
  5. 5.
    Hamberger A, Butcher SP, Hagberg H, Jacobsen I, Lehmann A, Sandberg M (1986) Extracellular concentration of excitatory amino acids: Effects of hyperexcitation, hypoglycaemia and ischaemia. In: Roberts PJ, Storm-Mathison J, Bradford HF (eds) Excitatory amino acids. MacMillan Press, London, pp 409–422Google Scholar
  6. 6.
    Miller JD, Bullock R, Graham DI et al (1990) Ischaemic brain damage in a model of acute subdural haematoma. Neurosurgery (in press)Google Scholar
  7. 7.
    Rothman SM, Olney JW (1986) Glutamate and the pathophysiology of hypoxic ischaemic brain damage. Ann Neurol 19: 105–111PubMedCrossRefGoogle Scholar
  8. 8.
    Sakurada O, Kennedy C, Jehle JW et al (1978) Measurements of local cerebral blood flow with 14C Iodo-antipyrene. Am J Pyhsiol 234: H59 - H66Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. Bullock
    • 1
  • S. Butcher
  • J. McCulloch
  1. 1.University Department of Neurosurgery, Institute of Neurological SciencesSouthern General HospitalGlasgowScotland

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