Effect of Murine Recombinant Interleukin-1 on Brain Oedema in the Rat
We investigated the effects of murine recombinant interleukin-1⌣(rIL-1, Du Pont) in vivo in the normal rat brain and here report both local and systemic effects of centrally administered rIL-1. Normal rats were given single or multiple atraumatic doses of either rIL1 or and equal volume (5 µl) of vehicle for control comparison. All dosages of intraparenchymal rIL-1 produced a uniform a hyperthermic response and concomitant lethargy. There was a related anorexia beyond fever duration. Histologic examination of intraparenchymal injection tracts revealed fibrillary whorls of oedema and a cellular infiltrate surrounding the rIL-1 tract, while similar changes were less prominent in control injection tracts. Repeated high doses of rIL-1 produced significantly higher concentrations of brain water as measured by the gravimetric technique. We conclude that rIL-1 is not only a potent chemoattractant, but is also an edigematic agent when adminstered in high doses.
KeywordsBrain Oedema Bromo Benzene Cellular Infiltrate Brain Water Content Multiple Daily Injection
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