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Effect of Murine Recombinant Interleukin-1 on Brain Oedema in the Rat

  • C. R. Gordon
  • R. S. Merchant
  • C. D. Rice
  • J. T. Marsh
  • H. F. Young
  • A. Marmarou
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

We investigated the effects of murine recombinant interleukin-1⌣(rIL-1, Du Pont) in vivo in the normal rat brain and here report both local and systemic effects of centrally administered rIL-1. Normal rats were given single or multiple atraumatic doses of either rIL1 or and equal volume (5 µl) of vehicle for control comparison. All dosages of intraparenchymal rIL-1 produced a uniform a hyperthermic response and concomitant lethargy. There was a related anorexia beyond fever duration. Histologic examination of intraparenchymal injection tracts revealed fibrillary whorls of oedema and a cellular infiltrate surrounding the rIL-1 tract, while similar changes were less prominent in control injection tracts. Repeated high doses of rIL-1 produced significantly higher concentrations of brain water as measured by the gravimetric technique. We conclude that rIL-1 is not only a potent chemoattractant, but is also an edigematic agent when adminstered in high doses.

Keywords

Brain Oedema Bromo Benzene Cellular Infiltrate Brain Water Content Multiple Daily Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McClain CM, Cohen D, Ott L, Dinarello CA, Young B (1987) Ventricular fluid interleukin-I activity in patients with head injury. J Lab Clin Med 110: 48–54PubMedGoogle Scholar
  2. 2.
    Marmarou A, Tanaka K, Shulman K (1982) An improved gravimetric measure of cerebral oedema. J Neurosurg 56: 246–253PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • C. R. Gordon
    • 1
  • R. S. Merchant
    • 1
  • C. D. Rice
    • 1
  • J. T. Marsh
    • 1
  • H. F. Young
    • 1
  • A. Marmarou
    • 2
  1. 1.Division of NeurosurgeryMedical College of VirginiaRichmondUSA
  2. 2.Division of NeurosurgeryMedical College of VirginiaRichmondUSA

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