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Development of Regional Cerebral Oedema After Lateral Fluid-Percussion Brain Injury in the Rat

  • T. K. McIntosh
  • H. Soares
  • M. Thomas
  • K. Cloherty
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

Most studies attempting to characterize post-traumatic oedema formation have focused on the acute postinjury period. We have recently developed a new model of lateral (parasagittal) fluidpercussion (FP) brain injury in the rat. The purpose of the present study was to characterize the temporal course of oedema formation and resolution in this experimental model of brain injury. Male Sprague-Dawley rats (n = 67) were anaesthetized and subjected to FP brain injury of moderate severity. Animals were sacrified at 1 hour, 6 hours, 24 hours, 2 days, 3 days, 5 days and 7 days after brain injury, brains removed and assayed for water content using either specific gravitimetric or wet weight/dry weight techniques. In the injured left parietal cortex, a significant increase in water content was observed by 6 hours postinjury (p < 0.05) that persisted up to 5 days postinjury. A prolonged and significant increase in water content was also observed in the left (ipsilateral) hippocampus which began at 1 hour postinjury (p < 0.05) and continued up to 3 days. Other regions examined showed no significant regional oedema after brain injury. These results suggest that lateral FP brain injury produces an early focus oedema that persists for a prolonged period after trauma. This model may be useful in the evaluation of novel pharmacological therapies designed to reduce cerebral oedema after brain injury.

Keywords

Traumatic Brain Injury Brain Injury Oedema Formation Tissue Water Content Weight Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • T. K. McIntosh
    • 1
  • H. Soares
    • 1
  • M. Thomas
    • 1
  • K. Cloherty
    • 1
  1. 1.CNS Injury Laboratory, Surgical Research Center Department of SurgeryUniversity of Connecticut Health CenterFarmingtonUSA

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