Nimodipine Attenuates Both Ischaemia-induced Brain Oedema and Mortality in a Rat Novel Transient Middle Cerebral Artery Occlusion Model

  • H. Hara
  • H. Nagasawa
  • K. Kogure
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


A novel transient middle cerebral artery (MCA) occlusion model in rats was used to evaluate the effects of nimodipine on 45Ca accumulation, brain oedema and mortality. Nimodipine (1 µg/kg/min, IV, 30 min) administered immediately after 3 hr of transient unilateral MCA occlusion significantly attenuated the post-ischaemic increase of tissue water content, partly 45Ca accumulation in the parietotemporal and frontal cortices ipsilateral to the left MCA occlusion 3 hr after reperfusion. Nimodipine decreased the mortality rate at 6 and 9 hr time points after recirculation, although the survival rate at the 24 hr point after recirculation was not different from the control group. These results suggest that nimodipine has beneficial effects in the early phase of reperfusion period.


Middle Cerebral Artery Occlusion Brain Oedema Focal Cerebral Ischaemia Cereb Blood Flow Cytosolic Free Calcium 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • H. Hara
    • 2
  • H. Nagasawa
    • 1
  • K. Kogure
    • 1
  1. 1.Department of Neurology, Institute of Brain DiseasesTohoku University School of MedicineSendaiJapan
  2. 2.Department of Neurology, Institute of Brain DiseasesTohoku University School of MedicineAoba-ku, Sendai 980Japan

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