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Brain Edema VIII pp 251–253Cite as

Nimodipine Attenuates Both Ischaemia-induced Brain Oedema and Mortality in a Rat Novel Transient Middle Cerebral Artery Occlusion Model

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Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

Summary

A novel transient middle cerebral artery (MCA) occlusion model in rats was used to evaluate the effects of nimodipine on 45Ca accumulation, brain oedema and mortality. Nimodipine (1 µg/kg/min, IV, 30 min) administered immediately after 3 hr of transient unilateral MCA occlusion significantly attenuated the post-ischaemic increase of tissue water content, partly 45Ca accumulation in the parietotemporal and frontal cortices ipsilateral to the left MCA occlusion 3 hr after reperfusion. Nimodipine decreased the mortality rate at 6 and 9 hr time points after recirculation, although the survival rate at the 24 hr point after recirculation was not different from the control group. These results suggest that nimodipine has beneficial effects in the early phase of reperfusion period.

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Author information

Authors and Affiliations

  1. Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan

    H. Nagasawa & K. Kogure

  2. Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980, Japan

    H. Hara M.D.

Authors
  1. H. Hara M.D.
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  2. H. Nagasawa
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  3. K. Kogure
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

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© 1990 Springer-Verlag

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Hara, H., Nagasawa, H., Kogure, K. (1990). Nimodipine Attenuates Both Ischaemia-induced Brain Oedema and Mortality in a Rat Novel Transient Middle Cerebral Artery Occlusion Model. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_84

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  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_84

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

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