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Effects of Atrial Natriuretic Peptide on Ischaemic Brain Oedema Evaluated by the Proton Magnetic Resonance Method

  • S. Naruse
  • Y. Aoki
  • Y. Horikawa
  • C. Tanaka
  • T. Higuchi
  • T. Ebisu
  • S. Ueda
  • S. Kondo
  • T. Kiyota
  • H. Hayashi
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

The effect of atrial natriuretic peptide (ANP) on cerebral oedema in rats was examined by magnetic resonance (MR). After occlusion of the left middle cerebral artery (MCA) to induce cerebral ischaemia, rats received continuous infusion of ANP for 24 h at a total dose of 120 μg/kg or 150 μ/kg. Proton relaxation times (T1 and T2) of excised oedematous tissue were measured in vitro and the area of the oedematous region was determined in vivo by the use of magnetic resonance imaging (MRI). The administration of ANP was found to decrease the lengthening of both T1 and T2 in the oedematous tissues and shown by MRI to decrease the area of the oedematous region, compared with group receiving saline. The topographic observations in vivo suggest that ANP suppress the development of the oedematous region.

Keywords

Middle Cerebral Artery Occlusion Atrial Natriuretic Peptide Brain Oedema Atrial Natriuretic Factor Brain Water Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Naruse
    • 1
  • Y. Aoki
    • 1
  • Y. Horikawa
    • 1
  • C. Tanaka
    • 1
  • T. Higuchi
    • 1
  • T. Ebisu
    • 1
  • S. Ueda
    • 1
  • S. Kondo
    • 2
  • T. Kiyota
    • 2
  • H. Hayashi
    • 2
  1. 1.Department of NeurosurgeryKyoto Prefectural University of MedicineKyotoJapan
  2. 2.Pharmaceuticals Lab.Asahi Chemical Industry, Co., Ltd.KyotoJapan

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