Post-ischaemic Treatment with the Prostacycline Analogue TTC-909 Reduces Ischaemic Brain Injury
The effects of stable PGI analogue TTC-909 on CBF and glucose metabolism was studied in the chronic stage of cerebral ischaemia produced by occluding the distal MCA in SHRSP. Administration of TTC-909 (100 ng/kg/day during 7 days) prevented the development of ischaemic oedema and improved secondary metabolic derangement coupled to flow in postischaemic tissues, particularly in the ischaemic rim.
KeywordsMean Arterial Blood Pressure Cereb Blood Flow Local Cerebral Blood Flow Ischaemic Brain Cerebral Glucose Utilization
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