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Post-ischaemic Treatment with the Prostacycline Analogue TTC-909 Reduces Ischaemic Brain Injury

  • K. Shima
  • K. Ohashi
  • H. Umezawa
  • H. Chigasaki
  • Y. Karasawa
  • S. Okuyama
  • H. Araki
  • S. Otomo
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

The effects of stable PGI analogue TTC-909 on CBF and glucose metabolism was studied in the chronic stage of cerebral ischaemia produced by occluding the distal MCA in SHRSP. Administration of TTC-909 (100 ng/kg/day during 7 days) prevented the development of ischaemic oedema and improved secondary metabolic derangement coupled to flow in postischaemic tissues, particularly in the ischaemic rim.

Keywords

Mean Arterial Blood Pressure Cereb Blood Flow Local Cerebral Blood Flow Ischaemic Brain Cerebral Glucose Utilization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • K. Shima
    • 2
  • K. Ohashi
    • 1
  • H. Umezawa
    • 1
  • H. Chigasaki
    • 1
  • Y. Karasawa
    • 3
  • S. Okuyama
    • 3
  • H. Araki
    • 3
  • S. Otomo
    • 3
  1. 1.Department of NeurosurgeryNational Defense Medical CollegeSaitamaJapan
  2. 2.Department of NeurosurgeryNational Defense Medical CollegeTokorozawa, Saitama 359Japan
  3. 3.Research CenterTaisho Pharmaceutical Co., Ltd.SaitamaJapan

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