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Effects of Ebselen (PZ 51) on Ischaemic Brain Oedema After Focal Ischaemia in Cats

  • H. Johshita
  • T. Sasaki
  • T. Matsui
  • T. Hanamura
  • H. Masayasu
  • T. Asano
  • K. Takakura
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

Using a transorbital middle cerebral artery (MCA) occlusion model in cats, we evaluated the anti-oedema effects of a new anti-inflammatory agent, ebselen (PZ 51), on ischaemic cortical oedema caused by prolonged ischaemia and recirculation. Local cerebral blood flow was measured by the hydrogen clearance method in the MCA territory and the corresponding cortical specific gravity was assessed by a microgravimetric technique. Ebselen had no significant effect on normal and ischaemic lCBF, while it significantly ameliorated post-ischaemic hypoperfusion following recirculation. In the severely ischaemic regions, microgravimetry showed the beneficial effects on the ischaemic oedema caused by prolonged ischaemia and recirculation as well. Although the exact site of action is undetermined in this study, the observed effects of ebselen may be ascribed to this agent’s broad-spectrum of anti-inflammatory activities.

Keywords

Middle Cerebral Artery Middle Cerebral Artery Occlusion Focal Ischaemia Drug Treated Group Middle Cerebral Artery Territory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • H. Johshita
    • 1
  • T. Sasaki
    • 2
  • T. Matsui
    • 1
  • T. Hanamura
    • 1
  • H. Masayasu
    • 3
  • T. Asano
    • 1
  • K. Takakura
    • 1
  1. 1.Department of NeurosurgerySaitama Medical CenterJapan
  2. 2.Department of NeurosurgeryUniversity of TokyoJapan
  3. 3.Department of Medical Research DevelopmentDaiichi Pharmaceutical Co. Ltd.Japan

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