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Liposome-entrapped Superoxide Dismutase Ameliorates Infarct Volume in Focal Cerebral Ischaemia

  • S. Imaizumi
  • V. Woolworth
  • H. Kinouchi
  • S. F. Chen
  • R. A. Fishman
  • P. H. Chan
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

We studied the role of superoxide radicals in the pathogenesis of focal ischaemic brain injury using liposome-entrapped copper-zinc-superoxide dismutase which can penetrate the blood-brain barrier and cell membranes efficiently. Superoxide dismutase activities were significantly elevated in the blood and in the normal brain tissue 1, 2, 8, and 24 hours after a bolus intravenous administration of liposome-entrapped copper-zinc-superoxide dismutase. Copper-zinc-superoxide dismutase activities were also increased significantly in the ischaemic hemisphere and the contralateral cortex as well. The infarct sizes were reduced by 33%, 24% and 18%, respectively, for the anterior artery area, middle artery area, and posterior artery area by treatment at 24 hours following the injection of liposome-entrapped superoxide dismutase. These data demonstrate that superoxide radicals are important determinants of the size of an infarct following focal cerebral ischaemia, and that liposome-entrapped copper-zinc-superoxide dismutase may have pharmacological value for focal cerebral ischaemic injury.

Keywords

Infarct Size Focal Cerebral Ischaemia Left Common Carotid Artery Contralateral Cortex Bolus Intravenous Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Imaizumi
    • 1
  • V. Woolworth
    • 1
  • H. Kinouchi
    • 1
  • S. F. Chen
    • 1
  • R. A. Fishman
    • 1
  • P. H. Chan
    • 1
  1. 1.CNS Injury and Oedema Research Center, Department of NeurologySchool of MedicineSan FranciscoUSA

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