Relationship Between Cerebral Blood Flow and Blood-Brain Barrier Permeability of Sodium and Albumin in Cerebral Infarcts of Rats

  • S. Ishimaru
  • K.-A. Hossmann
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The permeability of the blood-brain barrier to sodium and albumin was investigated in rats following occlusion of the middle cerebral artery. Regional blood flow and unidirectional transfer coefficients of sodium and albumin were measured by triple tracer autoradiography, and tissue electrolyte content by atomic absorption spectroscopy. In sham-operated controls regional transfer coefficients of sodium ranged between 1.3 and 3.2 × 10−3 ml · g−1 · min−1; the transfer coefficient of albumin was below the detection limit of autoradiography. During the initial 4 h of vascular occlusion neither albumin nor sodium permeability changed although tissue sodium content increased from 56 ± 3 to 76 ± 8 µmol · g−1. After 24 h transfer coefficient of sodium rose to between 2.91 and 7.0 × 10−3ml g−1· min−1, and tissue sodium content to 90 ± 9 µmol · g−1. Despite this rise the net uptake rate of sodium was 4 to 60 times lower than the unidirectional influx, indicating that permeability changes of the blood-brain barrier are without relevance for the development of stroke oedema.


Transfer Coefficient Cerebral Blood Flow Middle Cerebral Artery Middle Cerebral Artery Occlusion Vascular Occlusion 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Ishimaru
    • 1
  • K.-A. Hossmann
    • 1
  1. 1.Abteilung für experimentelle NeurologieMax-Planck-Institut für neurologische ForschungCologneFederal Republic of Germany

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