Blood-Brain Barrier Disruption Following CPR in Piglets
We studied blood-brain barrier (BBB) integrity in immature piglets during and following cardiopulmonary resuscitation (CPR). As in our previous work in the dog, there was no disruption during CPR after eight minutes of cardiac arrest, or immediately following resuscitation using a small molecule, alpha-aminoisobutyric acid. However, unlike the dog, where the BBB remained intact, we found delayed disruption of the BBB four hours after resuscitation. Young animals may be more prone to a delayed increase in BBB permeability after cardiac arrest and CPR.
KeywordsCardiac Arrest Arterial Plasma Johns Hopkins Medical Institution Normal Cerebral Blood Flow Arterial Plasma Concentration
Unable to display preview. Download preview PDF.
- 1.Schleien CL, Koehler RC, Shaffner DH, Traystman RJ (1990) Blood-brain barrier integrity during cardiopulmonary resuscitation in dogs. Stroke 21: (in press)Google Scholar