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Blood-Brain Barrier Disruption Following CPR in Piglets

  • Conference paper
Brain Edema VIII

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

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Summary

We studied blood-brain barrier (BBB) integrity in immature piglets during and following cardiopulmonary resuscitation (CPR). As in our previous work in the dog, there was no disruption during CPR after eight minutes of cardiac arrest, or immediately following resuscitation using a small molecule, alpha-aminoisobutyric acid. However, unlike the dog, where the BBB remained intact, we found delayed disruption of the BBB four hours after resuscitation. Young animals may be more prone to a delayed increase in BBB permeability after cardiac arrest and CPR.

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References

  1. Schleien CL, Koehler RC, Shaffner DH, Traystman RJ (1990) Blood-brain barrier integrity during cardiopulmonary resuscitation in dogs. Stroke 21: (in press)

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Authors and Affiliations

  1. Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, MD, 21205, USA

    C. L. Schleien M.D., R. C. Koehler, D. H. Shaffner & R. J. Traystman

Authors
  1. C. L. Schleien M.D.
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  2. R. C. Koehler
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  3. D. H. Shaffner
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  4. R. J. Traystman
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

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© 1990 Springer-Verlag

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Schleien, C.L., Koehler, R.C., Shaffner, D.H., Traystman, R.J. (1990). Blood-Brain Barrier Disruption Following CPR in Piglets. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_72

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  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_72

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

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