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Blood-Brain Barrier Disruption Following CPR in Piglets

  • C. L. Schleien
  • R. C. Koehler
  • D. H. Shaffner
  • R. J. Traystman
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

We studied blood-brain barrier (BBB) integrity in immature piglets during and following cardiopulmonary resuscitation (CPR). As in our previous work in the dog, there was no disruption during CPR after eight minutes of cardiac arrest, or immediately following resuscitation using a small molecule, alpha-aminoisobutyric acid. However, unlike the dog, where the BBB remained intact, we found delayed disruption of the BBB four hours after resuscitation. Young animals may be more prone to a delayed increase in BBB permeability after cardiac arrest and CPR.

Keywords

Cardiac Arrest Arterial Plasma Johns Hopkins Medical Institution Normal Cerebral Blood Flow Arterial Plasma Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schleien CL, Koehler RC, Shaffner DH, Traystman RJ (1990) Blood-brain barrier integrity during cardiopulmonary resuscitation in dogs. Stroke 21: (in press)Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • C. L. Schleien
    • 1
  • R. C. Koehler
    • 1
  • D. H. Shaffner
    • 1
  • R. J. Traystman
    • 1
  1. 1.Department of Anesthesiology/Critical Care MedicineThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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