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Diffusion-Weighted MR Imaging and T2-Weighted MR Imaging in Acute Cerebral Ischaemia: Comparison and Correlation with Histopathology

  • R. J. Sevick
  • J. Kucharczyk
  • J. Mintorovitch
  • M. E. Moseley
  • N. Derugin
  • D. Norman
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

Diffusion-weighted MR imaging is a new technique which measures the microscopic motion of water protons. Signal hyperintensity on diffusion-weighted images correlates closely with evidence of ischaemic damage on histopathologic sections. Following occlusion of the middle cerebral artery (MCA), diffusion-weighted images indicate the presence of early pathophysiologic changes occurring first in the basal ganglia and, subsequently, in cortical gray matter within the MCA vascular territory. Diffusion-weighted images also better define the anatomic locus of ischaemic tissue injury than T2-weighted images. Diffusion-weighted imaging thus appears to facilitate early detection and thereby possible therapeutic intervention in patients with acute stroke.

Keywords

Middle Cerebral Artery Occlusion Water Proton Signal Hyperintensity Triphenyl Tetrazolium Chloride Triphenyl Tetrazolium Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. J. Sevick
    • 1
  • J. Kucharczyk
    • 1
  • J. Mintorovitch
    • 1
  • M. E. Moseley
    • 1
  • N. Derugin
    • 1
  • D. Norman
    • 1
  1. 1.Department of RadiologyUniversity of CaliforniaSan FranciscoUSA

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