Diffusion-Weighted MR Imaging and T2-Weighted MR Imaging in Acute Cerebral Ischaemia: Comparison and Correlation with Histopathology
Diffusion-weighted MR imaging is a new technique which measures the microscopic motion of water protons. Signal hyperintensity on diffusion-weighted images correlates closely with evidence of ischaemic damage on histopathologic sections. Following occlusion of the middle cerebral artery (MCA), diffusion-weighted images indicate the presence of early pathophysiologic changes occurring first in the basal ganglia and, subsequently, in cortical gray matter within the MCA vascular territory. Diffusion-weighted images also better define the anatomic locus of ischaemic tissue injury than T2-weighted images. Diffusion-weighted imaging thus appears to facilitate early detection and thereby possible therapeutic intervention in patients with acute stroke.
KeywordsMiddle Cerebral Artery Occlusion Water Proton Signal Hyperintensity Triphenyl Tetrazolium Chloride Triphenyl Tetrazolium Chloride
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