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Suppression of Water Shift into Intracellular Space by TA-3090 (Calcium Entry Blocker) Measured with NMR

  • M. Yamamoto
  • M. Haida
  • R. Taniguchi
  • K. Yazaki
  • D. Kurita
  • M. Fukuzaki
  • Y. Shinohara
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

In order to clarify the effects of TA-3090 (calcium entry blocker) on the suppression of water after ischaemic events, 16 measurements of T2f were continuously performed on brain biopsy (for 2–60 min) obtained from treated and control Wistar rats. The time constant (k) and NMR parameters (T2f,(○) ∆ T2f, T2fmax(T2f(○) + ∆ T2f) were obtained from 16 values of T2f. The values of k in Wistar rats treated with intravenously administrated TA-3090 (0.5 mg/kg) were significantly prolonged as compared to that of control. There were no significant differences of maximum prolongation of T2f(T2fmax(T2f(○) + ∆ T2f) among three groups. Since the prolongation of T2f after biopsy reflects the water shift from extra to intracellular space, the increments of time constant indicates that TA-3090 suppresses the water shift into intracellular space. Our present results suggest that TA-3090 prevents some processes involved in irreversible cell damage and suppresses the cytotoxic brain oedema in the incomplete ischaemic area where non-competitive calcium channel is inactive.

Keywords

Intracellular Space Cereb Blood Flow Calcium Entry Blocker Nuclear Magnetic Resonance Parameter Water Shift 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Yamamoto
    • 1
  • M. Haida
    • 1
  • R. Taniguchi
    • 1
  • K. Yazaki
    • 1
  • D. Kurita
    • 1
  • M. Fukuzaki
    • 1
  • Y. Shinohara
    • 1
  1. 1.Department of NeurologyTokai University School of MedicineKanagawaJapan

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