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Effect of Glutamate and Its Antagonist on Shift of Water from Extra- to Intracellular Space After Cerebral Ischaemia

  • Y. Shinohara
  • M. Yamamoto
  • M. Haida
  • K. Yazaki
  • D. Kurita
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

The effects of glutamate and the excitatory amino acid antagonist, MK-801, were investigated on the time course of the shift of water from extracellular to intracellular space (progression or cytotoxic oedema) after total brain ischaemia in rats.

Administration of sodium glutamate intravenously before ischaemia accelerated the shift of water dose-dependently. On the contrary, preischaemic administration of MK-801, an NMDA antagonist, delayed the progression of cytotoxic oedema due to brain ischaemia.

We consider that glutamate and NMDA antagonists may have important roles in the development and prevention of cytotoxic oedema in the ischaemic state.

Keywords

Nuclear Magnetic Resonance NMDA Antagonist Intracellular Space Cereb Blood Flow Cytotoxic Oedema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Y. Shinohara
    • 1
  • M. Yamamoto
    • 1
  • M. Haida
    • 1
  • K. Yazaki
    • 1
  • D. Kurita
    • 1
  1. 1.Department of NeurologyTokai University, School of MedicineIsehara, KanagawaJapan

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