The Role of Endothelial Second Messenger’s-Generating System in the Pathogenesis of Brain Oedema
Part of the
book series (NEUROCHIRURGICA, volume 51)
The role of second messengers in the regulation of protein phosphorylation was studied in microvessels isolated from rat cerebral cortex. Calcium-calmodulin (CAM)-, Ca2+ /phospholipid (PK C)-, cyclic GMP (cGMP)-, and cyclic AMP (cAMP)-dependent protein kinases were detected. Autophosphorylation of both the α- and ß- subunits of CAM-dependent protein kinase and the proteolytic fragment of the PK C enzyme was also detected.
In other experiments, the effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain oedema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain.
KeywordsBrain Oedema Carotid Artery Occlusion Cerebral Endothelial Cell Bilateral Occlusion Brain Oedema Formation
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