The Role of Endothelial Second Messenger’s-Generating System in the Pathogenesis of Brain Oedema

Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The role of second messengers in the regulation of protein phosphorylation was studied in microvessels isolated from rat cerebral cortex. Calcium-calmodulin (CAM)-, Ca2+ /phospholipid (PK C)-, cyclic GMP (cGMP)-, and cyclic AMP (cAMP)-dependent protein kinases were detected. Autophosphorylation of both the α- and ß- subunits of CAM-dependent protein kinase and the proteolytic fragment of the PK C enzyme was also detected.

In other experiments, the effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain oedema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain.


Brain Oedema Carotid Artery Occlusion Cerebral Endothelial Cell Bilateral Occlusion Brain Oedema Formation 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • F. Joó
    • 1
  1. 1.Laboratory of Molecular Neurobiology, Institute of BiophysicsBiological Research CenterSzegedHungary

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