Summary
Survival, quantitative morphology of the hippocampus, cerebral tissue impedance and regional cerebral blood flow (rCBF) were studied in the Mongolian gerbil after 15 minutes of bilateral common carotid occlusion. A subgroup of animals was placed in cages with free access to running-wheels for two weeks preceeding ischaemia to measure voluntary locomotor activity. Survival was enhanced in the running-wheel subgroup, with 90% of the animals still alive after 14 days as compared to 48% of the non-running group. Neuronal loss was found in all animals in the hippocampus (CA 1, CA 2, CA 3 and CA 4), and was most pronounced in the CA 1 sector. In the running-wheel group, however, neuronal loss was significantly lower in sectors CA 2, CA 3 and CA 4. The increases of cerebral impedance, which indicate ischaemic cell swelling, reached 190% in both groups during ischaemia. During postischaemic recirculation, however, impedance normalized more rapidly in the running-wheel group, indicating earlier resolution of ischaemic cell swelling. In wheel-running gerbils, postischaemic hyperperfusion evolved earlier and was more pronounced as compared to non-runners. No differences in systemic blood pressure were observed during cerebral ischaemia or thereafter.
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© 1990 Springer-Verlag
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Stummer, W., Weber, K., Schürer, L., Baethmann, A., Kempski, O. (1990). Electrical Impedance, rCBF, Survival and Histology in Mongolian Gerbils with Forebrain Ischaemia. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_60
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DOI: https://doi.org/10.1007/978-3-7091-9115-6_60
Publisher Name: Springer, Vienna
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