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Restoration of Energy Metabolism and Resolution of Oedema Following Profound Ischaemia

  • K. L. Allen
  • A. L. Busza
  • E. Proctor
  • S. R. Williams
  • N. Van Bruggen
  • D. G. Gadian
  • H. A. Crockard
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

Cerebral ischaemia was produced in 2 groups of gerbils by occlusion of the common carotid arteries for 30 minutes, resulting in cerebral oedema. In group 1 cerebral oedema was measured by specific gravity microgravimetry, and in group 2 brain metabolism and blood flow were measured by 31P and 1H NMR spectroscopy and hydrogen clearance respectively. In group 1 the brain water content did not return to control levels by 180 minutes of reperfusion. Energy metabolism, determined by 31P NMR spectroscopy returned to control by 12 minutes, intracellular pH (pH1) by 20 minutes, and lactate, determined by 1H NMR spectroscopy, by 50 minutes. There was a lag of about 10 minutes before lactate began to be cleared from the brain. We suggest that while pH, is low, Na+/H+ exchange will negate the Na extrusion driven by the Na+/K+ ATPase. When pHi approaches normal there will be a net extrusion of Na+, taking osmotic water with it, and presumably with passive washout of lactate. This may be the cause of the initial delay in lactate clearance.

Keywords

Cerebral Oedema Brain Water Content Lactate Clearance Nervous System Damage Hydrogen Clearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Marmarou A, Poll W, Shulman K, Bhagavan H (1978) A simple gravimetric technique for measurement of cerebral oedema. J Neurosurg 49: 530–537PubMedCrossRefGoogle Scholar
  2. 2.
    Gadian DG, Frackowiak RSJ, Crockard HA, Proctor E, Allen K, Williams SR, Ross Russell RW (1987) Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and ‘H nuclear magnetic resonance spectroscopy. I. Methodology. J Cereb Blood Flow Metab 7: 199–206PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • K. L. Allen
    • 1
  • A. L. Busza
    • 2
  • E. Proctor
    • 2
  • S. R. Williams
    • 2
  • N. Van Bruggen
    • 2
  • D. G. Gadian
    • 2
  • H. A. Crockard
    • 1
  1. 1.Institute of Neurology, London, U.K.LondonUK
  2. 2.Royal College of SurgeonsLondonUK

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