Evaluation of Glucose Transport in Malignant Glioma by PET

  • M. Ishikawa
  • H. Kikuchi
  • S. Nishizawa
  • Y. Yonekura
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


Using dynamic PET mode and 18FDG, glucose transport in patients with gliomas were investigated. The values for transfer rate constants kl*, k2*, k3*, and glucose consumption were found to be low in the low-grade glioma as compared to those of the high-grade glioma and the contralateral cerebral cortex. The differences were statistically significant with the exception of k2*. There were no statistically significant differences between the high-grade glioma and the contralateral cerebral cortex. In contrast, the distribution volumes k1*/ k2* and k1*/(k2*+k3*) were low in high-grade glioma and the difference between the high-grade glioma and the contralateral cerebral cortex was statistically significant. A difference in k1*/ (k2*+k3*) was noted between the low-grade and the high-grade gliomas. Thus, the distribution volumes are most sensitive for differentiation between high-grade glioma and cerebral cortex.


Positron Emission Tomography Glucose Transport Malignant Glioma Human Glioma Glucose Consumption 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Brooks DJ, Beaney RP, Lammertsma AA, Herold S, Turton DR, Luhra SK, Franckowiak RSJ, Thomas DGT, Marshall J, Jones T (1986) Glucose transport across the blood-brain barrier in normal human subjects and patients with cerebral tumours studied using [11C3-O- Methyl-D-Glucose and positron emission tomography. J Cereb Blood Flow Metab 6: 230–239PubMedCrossRefGoogle Scholar
  2. 2.
    DiChiro G, Brooks RA, Bairamian D, Patronas NJ, Kornblith PL, Smith BH, Mansi L (1985) Diagnostic and prognostic value of positron emission tomography using (18F)-fluorodeoxyglucose in brain tumours. In: Reivich M, Alavi A (eds) Positron emission tomography. Alan R. Liss, Inc., New York, pp 291–301Google Scholar
  3. 3.
    Hawkins RA, Phelps ME, Huang SC (1986) Effects of temporal sampling, glucose metabolic rates, and disruptions of the blood-brain barrier on the FDG model with and without a vascular compartment: Studies in human brain tumours with PET. J Cereb Blood Flow Metab 6: 170–183Google Scholar
  4. 4.
    Koeppe RA, Junck L, Chen Y, Belley AT, Hutchins AT, Rodley JM, Hichwa RS (1987) Differentiation between glucose transport and phosphorylation processes in brain tumours by dynamic PET and FDG. J Cereb Blood Flow Metab 7 [Suppl 1]: S 482Google Scholar
  5. 5.
    Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff K, Kuhl DE (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (18-F)-L-fluoro-2-deoxy-D-glucose; validation of method. Ann Neurol 6: 371–388PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Ishikawa
    • 3
  • H. Kikuchi
    • 1
  • S. Nishizawa
    • 2
  • Y. Yonekura
    • 2
  1. 1.Departments of NeurosurgeryKyoto UniversityJapan
  2. 2.Nuclear Medicine Faculty of MedicineKyoto UniversityJapan
  3. 3.Department of Neurosurgery, Faculty of MedicineKyoto UniversitySakyo-ku, Kyoto 606Japan

Personalised recommendations