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Novel 21-aminosteroids Prevent Tumour Associated Neurological Dysfunction

  • W. A. King
  • K. L. Black
  • K. Ikezaki
  • S. Conklin
  • D. P. Becker
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

The efficacy of the potent lipid peroxidation inhibitors U-74006F and U-78517F in the treatment of blood-tumour barrier permeability and tumour associated neurological dysfunction was evaluated. Rats with stereotactically implanted Walker 256 tumours were treated with methylprednisolone (MP), U-74006F, U-78517F, or vehicle. (0.05 N HC1) on days 6 through 10 following implantation. Neurologic function and vascular permeability was assessed on day 10. U-74006F and MP were equally effective at preventing neurologic dysfunction compared to control (p <0.01). U-78517F was slightly less effective than U-74006F and MP but was significantly better than vehicle in preventing neurological dysfunction. MP resulted in a significant decrease in tumour vascular permeability (p <0.006) while the lipid peroxidation inhibitors had no effect on permeability.

Keywords

Vascular Permeability Cerebral Vasospasm Maximal Tumour Diameter Experimental Spinal Cord Injury Tumour Vascular Permeability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • W. A. King
    • 2
  • K. L. Black
    • 1
  • K. Ikezaki
    • 1
  • S. Conklin
    • 1
  • D. P. Becker
    • 1
  1. 1.Brain Research Institute, Jonsson Cancer Center and Division of NeurosurgeryUCLA School of MedicineLos AngelesUSA
  2. 2.Division of Neurosurgery, 74–140 CHSUCLA School of MedicineLos AngelesUSA

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