The Effect of the Aminosteroid U-78517G on Peritumoural Brain Oedema

  • E. Arbit
  • A. Rubinstein
  • G. DiResta
  • J. Lee
  • F. Ali
  • J. H. Galicich
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


U-78517G belongs to a novel group of compounds-aminosteroids (AS) wich are potent inhibitors of central nervous system tissue lipid peroxidation and are devoid of classical glucocorticoid and mineralocorticoid activities. The AS have been found to possess cerebral protective properties against ischaemia, ischaemic oedema, trauma to the cerebrum and spinal cord and in sub-arachnoid hemorrhage. The possible efficacy of U-78517G in attenuating peritumoural oedema was examined in rats harbouring cerebral 9L gliosarcomas. 19 Sprague-Dawley rats were implanted intracranially with 9L gliosarcoma cells. On day 14 post implantation rats were randomized to control (no treatment n = 10) and AS treated animals (n = 9). On day 20 animals were sacrificed and six brain samples per rat were examined for the percentage of water content. Oedema was assessed with the wet/dry weight technique. The AS treated animals were found to have a significant increase in peritumoural oedema (+ 1.38%, P<0.001) possibly related to an increase in cerebral blood flow associated with AS treatment. Further studies are, however, underway to precisely clarify this unexpected observation.


Brain Oedema Mineralocorticoid Activity Peritumoural Oedema Classical Side Iron Dependent Lipid Peroxidation 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • E. Arbit
    • 2
  • A. Rubinstein
    • 1
  • G. DiResta
    • 1
  • J. Lee
    • 1
  • F. Ali
    • 1
  • J. H. Galicich
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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