Summary
Following infusion of 200 ml of Iopamidol for 1 hour the propagation of extravasated contrast medium around different types of 12 brain tumours was examined and imaged via CT. Increasing volume of expanding peritumoural contrast enhanced brain tissue was measured by integrating volumes of planimetrically measured enhanced area on CT slice of 0.5 cm in thickness. So far our data failed to demonstrate differences in the peritumoural contrast expansion between the different types of tumours. Formation and resolution as well as the speed of oedema propagation were determined by calculation of the increasing volume of the enhanced peritumoural brain tissue. Average formation rate of oedema fluid from 1 cm3 of tumour was 0.06 ml/hr, and was lower in larger tumours, while formation rate of oedema fluid from whole tumour was higher in larger tumours. Average resolution rate of oedema fluid during the passage through 1 cm3 of the peritumoural white matter was 0.03 ml/hr, and was not affected by tumour size. Average speed of oedema propagation was 0.59 mm/hr, and was higher in larger tumours. The main therapeutic effect of steroid in peritumoural oedema was a reduction in formation rate of oedema fluid.
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References
Fenske A, Samii M, Reulen H-J et al. (1973) Extracellular space and electrolyte distribution in cortex and white matter of dog brain in cold induced oedema. Acta Neurochir (Wien) 28: 81–94
Hossmann KA, Blanik M, Wilmes F, Wechsler W (1980) Experimental peritumoural oedema of the cat brain. In: CervosNavaro J, Ferszt R (eds), Brain oedema. Advances in neurology, vol 28. Raven Press, New York, pp 323–340
Ito U, Reulen H-J, Huber P (1986) Spatial and quantitative distribution of human peritumoural brain ooedema in computerized tomography. Acta Neurochir (Wien) 81: 53–60
Ito U, Reulen H-J, Tomita H, Ikeda J, Saito J, Maehara T (1988) Formation and propagation of brain ooedema fluid around human brain metastases. A CT study. Acta Neurochir (Wien) 90: 35–41
Ito U, Tomita H, Reulen H-J, Maehara T, Kohmo Y, Ito Y (1989) A CT study on formation, propagation and resolution of brain oedema fluid in human peritumoural oedema. In: Hoff JT, Betz AL (eds), Intracranial pressure VII. Springer, Berlin Heidelberg New York, pp 959–965
Lanksch WR (1982) The dignosis of brain oedema by computed tomography. In: Hartmann A, Brock M (eds), Treatment of cerebral oedema. Springer, Berlin Heidelberg New York, pp 43–80
Reulen H-J, Graham R, Spatz M, Klatzo I (1977) Role of pressure gradients and bulk flow in dynamics of vasogenic brain oedema. J Neurosurg 46: 24–35
Reulen H-J, Graber S, Huber P, Ito U (1988) Factors affecting the extension of peritumoural brain ooedema. A CT-study. Acta Neurochir (Wien) 95: 19–24
Tamura A, Matsutani M, Nakagomi T, Nagashima T, Tsujita Y, Sano K (1988) Changes of capillary permeability in experimental brain tumour. Brain and Nerve 40: 149–156 (in Japanese with English abstract)
Yamada K, Bremer AM, West CR (1979) Effects of dexamethasone on tumour-induced brain oedema and its distribution in the brain of monkeys. J Neurosurg 50: 361–367
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© 1990 Springer-Verlag
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Ito, U., Tomita, H., Tone, O., Shishido, T., Hayashi, H. (1990). Formation and Resolution of White Matter Oedema in Various Types of Brain Tumours. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_50
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DOI: https://doi.org/10.1007/978-3-7091-9115-6_50
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