Summary
In the experimental F98 rat glioma model the nuclear magnetic resonance contrast agent MnTPPS was used to increase the contrast between tumour and peritumourous brain tissue. By evaluating pre-and postcontrast CPMG echo trains after different dose and circulation times of MnTPPS, the transverse relaxation time T2, the magnetization extrapolated to the time zero M (0), and the contrast ratio Rc of the magnetizations in neoplastic and normal tissues were determined. According to these data a maximum contrast is obtained a few hours after injection of 0.25 mmol MnTPPS/kg bw, using spin echo pulse sequences with short repetition times TR (1,100 ms), and short spin echo time TE (25 ms).
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References
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© 1990 Springer-Verlag
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Bockhorst, K., Hoehn-Berlage, M., Kocher, M., Hossmann, KA. (1990). MRI Contrast Enhancement by MnTPPS of Experimental Brain Tumours in Rats. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_45
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DOI: https://doi.org/10.1007/978-3-7091-9115-6_45
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