MRI Contrast Enhancement by MnTPPS of Experimental Brain Tumours in Rats

  • K. Bockhorst
  • M. Hoehn-Berlage
  • M. Kocher
  • K.-A. Hossmann
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


In the experimental F98 rat glioma model the nuclear magnetic resonance contrast agent MnTPPS was used to increase the contrast between tumour and peritumourous brain tissue. By evaluating pre-and postcontrast CPMG echo trains after different dose and circulation times of MnTPPS, the transverse relaxation time T2, the magnetization extrapolated to the time zero M (0), and the contrast ratio Rc of the magnetizations in neoplastic and normal tissues were determined. According to these data a maximum contrast is obtained a few hours after injection of 0.25 mmol MnTPPS/kg bw, using spin echo pulse sequences with short repetition times TR (1,100 ms), and short spin echo time TE (25 ms).


Contrast Ratio Transverse Relaxation Time Spin Echo Pulse Sequence Experimental Glioma Experimental Brain Tumour 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • K. Bockhorst
    • 1
  • M. Hoehn-Berlage
    • 2
  • M. Kocher
    • 1
  • K.-A. Hossmann
    • 1
  1. 1.Abteilung für experimentelle NeurologieMax-Planck-Institut für neurologische ForschungCologneFederal Republic of Germany
  2. 2.Abteilung für experimentelle NeurologieMax-Planck-Institut für neurologische ForschungKöln 41Federal Republic of Germany

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