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Effects of Atrial Natriuretic Peptide on Brain Oedema: The Change of Water, Sodium, and Potassium Contents in the Brain

  • S. Naruse
  • R. Takei
  • Y. Horikawa
  • C. Tanaka
  • T. Higuchi
  • T. Ebisu
  • S. Ueda
  • S. Sugahara
  • S. Kondo
  • T. Kiyota
  • H. Hayashi
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

We examined the effect of atrial natriuretic peptide (ANP) administration on cerebral oedema in rats. Intravenous ANP infusion with total dose of 120 µg/kg and 100 µg/kg suppressed the elevation of water and Na contents in left middle cerebral artery (MCA) occluded and cold injured brain tissue, indicating that ANP has a suppressive effect on cerebral oedema. Similar ANP infusion at a low dose of 1.tg/kg/h for 6 h also resulted in observation of the anti-oedematous effect in both models, with no observable occurrence of the known systemic effects of ANP on systolic blood pressure (SBP), heart rate (HR), hematocrit, or serum electrolyte ion (Na+, K+, Cl) concentrations. The results thus suggest that the anti-oedematous effect of ANP is attributable to water and Na content control by ANP specific to the damaged tissue, possibly through inhibition of sodium transport. Taken together with a recent study in which it was shown that ANP might inhibit sodium transport in cerebral microvessel, our results suggest that ANP suppresses the development of brain oedema by inhibiting sodium transport and the coupled water influx.

Keywords

Middle Cerebral Artery Occlusion Atrial Natriuretic Peptide Brain Oedema Guanylate Cyclase Atrial Natriuretic Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    de Bold AJ (1985) Atrial natriuretic factor: a hormone produced by the heart. Science 230: 767–770PubMedCrossRefGoogle Scholar
  2. 2.
    Chinkers M, Garbers DL, Chang MS, Lowe DG, Chin H, Goeddel DV, Schulz S (1989) A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature 338: 78–83PubMedCrossRefGoogle Scholar
  3. 3.
    Dóczi T, Joó F, Szerdahelyi P, Bodosi M (1987) Regulation of brain water and electrolyte contents: The possible involvement of central atrial natriuretic factor. Neurosurgery 21: 454–458PubMedCrossRefGoogle Scholar
  4. 4.
    Friedl A, Harmening C, Schmalz F, Schuricht B, Schiller M, Hamprecht B (1989) Elevation by atrial natriuretic factors of cyclic GMP levels in astroglia-rich cultures from murine brain. J Neurochem 52: 589–597PubMedCrossRefGoogle Scholar
  5. 5.
    Ibaragi M, Niwa M, Ozaki M (1989) Atrial natriuretic peptide modulates amiloride-sensitive Na+ transport across the blood-brain barrier. J Neurochem 53: 1802–1806PubMedCrossRefGoogle Scholar
  6. 6.
    Light DB, Schwiebert EM, Karlson KH, Stanton BA (1989) Atrial natriuretic peptide inhibits a cation channel in renal inner medullary collecting duct cells. Science 243: 383–385PubMedCrossRefGoogle Scholar
  7. 7.
    O’Donnell ME (1989) Regulation of Na-K-Cl cotransport in endothelial cells by atrial natriuretic factor. Am J Physiol 257: C36 - C44PubMedGoogle Scholar
  8. 8.
    Steardo L, Nathanson JA (1987) Brain barrier tissues: End organs for atriopeptins. Science 235: 470–473PubMedCrossRefGoogle Scholar
  9. 9.
    Tamura A, Graham DI, McCulloch J, Teasdale GM (1981) Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1: 53–60CrossRefGoogle Scholar
  10. 10.
    Weidmann P, Hasler L, Gnadinger MP, Lang RE, Uehlinger DE (1986) Blood levels and renal effects of atrial natriuretic peptide in normal man. J Clin Invest 77: 734–742PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Naruse
    • 2
  • R. Takei
    • 1
  • Y. Horikawa
    • 1
  • C. Tanaka
    • 1
  • T. Higuchi
    • 1
  • T. Ebisu
    • 1
  • S. Ueda
    • 1
  • S. Sugahara
    • 3
  • S. Kondo
    • 3
  • T. Kiyota
    • 3
  • H. Hayashi
    • 3
  1. 1.Department of NeurosurgeryKyoto Prefectural University of MedicineKyotoJapan
  2. 2.Department of NeurosurgeryKyoto Prefectural University of MedicineKamigyo-Ku, Kyoto 602Japan
  3. 3.Pharmaceuticals Lab.Asahi Chemical Industry, Co., Ltd.KyotoJapan

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