The Ambivalent Effects of Early and Late Administration of Mannitol in Cold-induced Brain Oedema
This study was undertaken in order to determine whether early administration of mannitol is different from late administration in its effect on brain oedema. Cold-induced brain oedema, which was confirmed by high resolution CT scan, was produced in 2 groups of cats. In group one mannitol was given early (90 minutes after injury); in group two 3–4 hours after the injury (late). Repeated CT scans following mannitol administration showed that the early group exhibited significantly greater dehydration (p < 0.0001) while the late group showed significant hydration, in the lesioned hemisphere. The contralateral control hemisphere responded to mannitol with similar dehydration effect in both groups.
KeywordsBrain Oedema Early Group Beer Sheva Water Gain Cold Probe
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- 3.Cooper PR (1985) Delayed brain injury: secondary insults. In: Becker DP, Povlishock JT (eds) Central nervous system trauma report. NINCDS p. 219 NIH Edition, Bethesda, MarylandGoogle Scholar
- 4.Fenstermacher J (1984) Volume regulation of the central nervous system. In: Staub NC, Taylor AE (eds) Oedema. Raven Press, New York, pp 383–404Google Scholar
- 6.Kaupp Jr HA, Lazarus RE, Wetzel N (1960) The role of cerebral oedema in ischaemic cerebral neuropathy after cardiac arrest in dogs and monkeys and its treatment with hypertonic urea. Surgery 18: 404–460Google Scholar
- 8.Reulen HJ, Tsuyumu M (1981) Pathophysiology of formation and natural resolution of vasogenic brain oedema. In: De Vlieger M, deLange S, Beks JWF (eds) Brain oedema. Wiley, New York, p 32Google Scholar