A Microstructural Study of Oedema Resolution

  • H. Naruse
  • K. Tanaka
  • S. Nishimura
  • K. Fugimoto
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The infusion model was used to investigate the resolution mechanism of vasogenic brain oedema. HRP dissolved in autoserum was infused into the white matter of cats. The infused protein in the oedema fluid seemed not only to be absorbed by pinocytosis or phagocytosis, as has been reported previously, but also to be quickly washed out via the perivascular space of the post-capillary venules. Smaller molecules such as HRP moved faster than serum albumin in these spaces after the infusion pump was turned off. Rapid flow of extracellular fluid via the perivascular space may play an important role on the resolution process of vasogenic brain oedema by accelerating diffusion


Dense Material Perivascular Space Microstructural Study Resolution Process Vasogenic Brain Oedema 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • H. Naruse
    • 3
  • K. Tanaka
    • 1
  • S. Nishimura
    • 1
  • K. Fugimoto
    • 2
  1. 1.Department of NeurosurgeryOsaka City University Medical SchoolOsakaJapan
  2. 2.The 1st Department of AnatomySimane Medical UniversityOsakaJapan
  3. 3.Department of NeurosurgeryOsaka City University Medical Schoolabeno-ku, Osaka 545Japan

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