Comparative Effects of Direct and Indirect Hydroxyl Radical Scavengers on Traumatic Brain Oedema

  • Y. Ikeda
  • D. M. Long
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The effects of dimethyl sulfoxide (DMSO) and dimethylthiourea (DMTU) and deferoxamine (DFO) were investigated in cats during a standard cortical freezing method for the production of vasogenic brain oedema. Hydroxyl radical scavenging activity was studied by electron spin resonance assay using DMPO as the trap. The hydroxyl radical spin adduct was extinguished by DFO and a large dose of DMTU. Evans blue dye extravasation was reduced in DFO and DMSO treated groups as well. DFO appears to be an effective agent for the prevention of cold induced oedema. DMSO and DMTU are direct hydroxyl radical scavengers. These studies suggest that scavenging the hydroxyl radicals has a beneficial effect in the treatment of traumatic brain oedema.


Brain Oedema Oxygen Free Radical Evans Blue Hydroxyl Radical Scavenger Hydroxyl Radical Scavenge Activity 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Y. Ikeda
    • 1
  • D. M. Long
    • 2
  1. 1.Department of NeurosurgeryNippon Medical SchoolTokyoJapan
  2. 2.Department of NeurosurgeryThe Johns Hopkins HospitalBaltimoreUSA

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