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Evaluation of Oedema Spreading and Intracranial Volume Reserve Using CT Image Numerical Analysis

  • Z. Czernicki
  • J. Walecki
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

Using the cold lesion model vasogenic oedema was produced in 8 cats. The intracranial volume reserve was evaluated applying CT image numerical analysis (CTINA). Summarizing all voxels corresponding to CSF and brain tissue in 8 CT slices, the brain/CSF ratio was computed. The animals were studied at different time intervals after the lesion (2 h, 4 h, 6 h) then sacrificed and the spreading of oedema was estimated based on the BBB disturbances. The brain/ CSF ratios varied from mean value of 0.043 in control animals to mean values of 0.022 in animals 6 hours after the lesion.

The CTINA method was found very useful as a noninvasive screening method to study brain oedema development with a promising application in clinical practice.

Keywords

Evans Blue Vasogenic Oedema Intracranial Volume Vasogenic Brain Oedema Oedema Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Czernicki Z (1979) Treatment of experimental brain oedema following sudden decompression, surgical wound and cold lesion with vasoprotective drugs and the proteinase inhibitor “Trasylol”. Acta Neurochir (Wien) 50: 311–326CrossRefGoogle Scholar
  2. 2.
    Czernicki Z, Walecki J, Jurkiewicz J, Grochowski W, Tychmanowicz K (1990) Intracranial volume reserve studies using CT images numerical analysis and lumbal infusion tests in cats. Przegl Radiol (in press)Google Scholar
  3. 3.
    Czernicki Z, Walecki J, Polacin A (1990) Intracranial volume reserve determination using CT images numerical analysis in trauma and tumour patients. Przegl Radiol (in press)Google Scholar
  4. 4.
    Reulen HJ, Graham R, Spatz M, Klatzo I (1977) Role of pressure gradients and bulk flow in dynamics of vasogenic brain oedema. J Neurosurg 46: 24–35PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Z. Czernicki
    • 2
  • J. Walecki
    • 1
  1. 1.Department of Neurosurgery, Medical Research CentrePolish Academy of SciencesWarsawPoland
  2. 2.Department of Neurosurgery, Medical Research CentrePolish Academy of SciencesWarsawPoland

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