Evaluation of Oedema Spreading and Intracranial Volume Reserve Using CT Image Numerical Analysis

  • Z. Czernicki
  • J. Walecki
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


Using the cold lesion model vasogenic oedema was produced in 8 cats. The intracranial volume reserve was evaluated applying CT image numerical analysis (CTINA). Summarizing all voxels corresponding to CSF and brain tissue in 8 CT slices, the brain/CSF ratio was computed. The animals were studied at different time intervals after the lesion (2 h, 4 h, 6 h) then sacrificed and the spreading of oedema was estimated based on the BBB disturbances. The brain/ CSF ratios varied from mean value of 0.043 in control animals to mean values of 0.022 in animals 6 hours after the lesion.

The CTINA method was found very useful as a noninvasive screening method to study brain oedema development with a promising application in clinical practice.


Evans Blue Vasogenic Oedema Intracranial Volume Vasogenic Brain Oedema Oedema Development 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Z. Czernicki
    • 2
  • J. Walecki
    • 1
  1. 1.Department of Neurosurgery, Medical Research CentrePolish Academy of SciencesWarsawPoland
  2. 2.Department of Neurosurgery, Medical Research CentrePolish Academy of SciencesWarsawPoland

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