Evaluation of Oedema Spreading and Intracranial Volume Reserve Using CT Image Numerical Analysis
Using the cold lesion model vasogenic oedema was produced in 8 cats. The intracranial volume reserve was evaluated applying CT image numerical analysis (CTINA). Summarizing all voxels corresponding to CSF and brain tissue in 8 CT slices, the brain/CSF ratio was computed. The animals were studied at different time intervals after the lesion (2 h, 4 h, 6 h) then sacrificed and the spreading of oedema was estimated based on the BBB disturbances. The brain/ CSF ratios varied from mean value of 0.043 in control animals to mean values of 0.022 in animals 6 hours after the lesion.
The CTINA method was found very useful as a noninvasive screening method to study brain oedema development with a promising application in clinical practice.
KeywordsEvans Blue Vasogenic Oedema Intracranial Volume Vasogenic Brain Oedema Oedema Development
- 2.Czernicki Z, Walecki J, Jurkiewicz J, Grochowski W, Tychmanowicz K (1990) Intracranial volume reserve studies using CT images numerical analysis and lumbal infusion tests in cats. Przegl Radiol (in press)Google Scholar
- 3.Czernicki Z, Walecki J, Polacin A (1990) Intracranial volume reserve determination using CT images numerical analysis in trauma and tumour patients. Przegl Radiol (in press)Google Scholar