Summary
The effect of gammahydroxybutyrate (GHB) on ICP, systemic arterial pressure and cerebral perfusion pressure in the experimentally induced brain oedema of the rat was examined. 400 mg/kg GHB reduced significantly ICP (11.74 ± 1.20 mm Hg; control: 16.20 ± 8.89 mm Hg; p<0.01) while increasing mean systemic arterial pressure (109.89 ± 6.35 mm Hg; control: 89,65 ± 4.22 mmHg; p<0.05) and cerebral perfusion pressure (98.11 ± 6.79 mm Hg; control: 73.84 ± 5.25 mm Hg; p<0.02). In the dose-effect curve 200 mg/ kg GHB show an increase in mean systemic arterial pressure from 89.60 ± 9.35 mm Hg to 97.60 ± 3.48 mm Hg (p<0.02) and 400 mg/ kg GHB to 108.00 ± 5.20 mm Hg (p<0.001) mean systemic arterial pressure. Thus, the decrease in intracranial pressure is not due to a reduction in the mean systemic arterial pressure, but GHB does reduce the ICP while increasing mean systemic arterial pressure and cerebral perfusion pressure. GHB may be a useful adjunct to neurosurgical therapy in controlling elevated ICP.
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© 1990 Springer-Verlag
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Plangger, C.A.M. (1990). Effect of Gammahydroxybutyrate on Intracranial Pressure, Mean Systemic Arterial Pressure and Cerebral Perfusion Pressure in Experimentally Induced Brain Oedema of the Rat. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_135
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DOI: https://doi.org/10.1007/978-3-7091-9115-6_135
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