Effect of Gammahydroxybutyrate on Intracranial Pressure, Mean Systemic Arterial Pressure and Cerebral Perfusion Pressure in Experimentally Induced Brain Oedema of the Rat
The effect of gammahydroxybutyrate (GHB) on ICP, systemic arterial pressure and cerebral perfusion pressure in the experimentally induced brain oedema of the rat was examined. 400 mg/kg GHB reduced significantly ICP (11.74 ± 1.20 mm Hg; control: 16.20 ± 8.89 mm Hg; p<0.01) while increasing mean systemic arterial pressure (109.89 ± 6.35 mm Hg; control: 89,65 ± 4.22 mmHg; p<0.05) and cerebral perfusion pressure (98.11 ± 6.79 mm Hg; control: 73.84 ± 5.25 mm Hg; p<0.02). In the dose-effect curve 200 mg/ kg GHB show an increase in mean systemic arterial pressure from 89.60 ± 9.35 mm Hg to 97.60 ± 3.48 mm Hg (p<0.02) and 400 mg/ kg GHB to 108.00 ± 5.20 mm Hg (p<0.001) mean systemic arterial pressure. Thus, the decrease in intracranial pressure is not due to a reduction in the mean systemic arterial pressure, but GHB does reduce the ICP while increasing mean systemic arterial pressure and cerebral perfusion pressure. GHB may be a useful adjunct to neurosurgical therapy in controlling elevated ICP.
KeywordsIntracranial Pressure Cerebral Perfusion Pressure Systemic Arterial Pressure Local Cerebral Blood Flow Systemic Arterial Blood Pressure
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