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Effect of Mannitol on Intracranial Pressure-Volume Status and Cerebral Haemodynamics in Brain Oedema

  • S. Inao
  • H. Kuchiwaki
  • A. Wachi
  • K. Andoh
  • M. Nagasaka
  • K. Sugita
  • M. Furuse
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

Continuous measurement of CBV and CBF by means of laser-Doppler flowmetry was performed to analyze the temporal profile of cerebrovascular response to water accumulation in an infusion model of brain oedema. Using this method, the effect of mannitol on CBV was also examined to determine how mannitol improves the intracranial pressure-volume relationship. The results show that:
  1. (1)

    The presence of an oedema generator elicits a continuous reduction of CBV and a transient reduction of CBF. With cessation of this mechanical force of oedema production, CBV and CBF return to control levels.

     
  2. (2)

    Mannitol increases CBV and PVI. The improvement of PVI might be due to an increase in CBV as well as ICP reduction.

     

Keywords

Brain Oedema Cerebral Blood Volume Normal White Matter Cerebral Haemodynamics Cerebrovascular System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Inao
    • 1
  • H. Kuchiwaki
    • 1
  • A. Wachi
    • 2
  • K. Andoh
    • 1
  • M. Nagasaka
    • 1
  • K. Sugita
    • 1
  • M. Furuse
    • 3
  1. 1.Department of NeurosurgeryNagoya University School of MedicineNagoyaJapan
  2. 2.Department of NeurosurgeryJuntendoh UniversityNagoyaJapan
  3. 3.Department of NeurosurgeryNakatsugawa Municipal General HospitalNagoyaJapan

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