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Blood Flow and Metabolism in Vasogenic Oedema

  • Conference paper
Brain Edema VIII

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

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Summary

The relationship between white matter cerebral blood flow (CBF) and glucose metabolism (LCMRgl) was studied in a plasma infusion model of vasogenic oedema in cats. LCBF as determined by iodoantipyrine was found to be significantly decreased in oedematous white matter (17.3 ± 1.5 m1/100 gm/min) when compared with contralateral control white matter (24.8 ± 1.8 ml/100 gm/min). If the values for oedematous brain were corrected for dilution, however, the LCBF averaged 25.3 ± 1.7 ml/100 gm/min, which was the same as control.

LCMRgl was found to be significantly increased in plasma-infused white matter (16.3 ± 2.2 µmol/ 100 gm/min), compared with control white matter (10.7 ± 1.3). This difference remained despite correction for dilution and recalculation of LCMRgl values based on altered kinetic constants found in oedematous brain. A similar increase in LCMRgl was noted with saline infusion oedema.

It is concluded that increased tissue water does not alter CBF, but does induce an increase in anaerobic metabolism.

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Author information

Authors and Affiliations

  1. School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    L. N. Sutton M.D., J. Greenberg & F. Welsh

  2. Children’s Hospital of Philadelphia, 34th Street & Civic Center Boulevard, Philadelphia, PA, 19104, USA

    L. N. Sutton M.D.

Authors
  1. L. N. Sutton M.D.
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  2. J. Greenberg
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  3. F. Welsh
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

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© 1990 Springer-Verlag

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Sutton, L.N., Greenberg, J., Welsh, F. (1990). Blood Flow and Metabolism in Vasogenic Oedema. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_133

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  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_133

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

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