Blood Flow and Metabolism in Vasogenic Oedema

  • L. N. Sutton
  • J. Greenberg
  • F. Welsh
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The relationship between white matter cerebral blood flow (CBF) and glucose metabolism (LCMRgl) was studied in a plasma infusion model of vasogenic oedema in cats. LCBF as determined by iodoantipyrine was found to be significantly decreased in oedematous white matter (17.3 ± 1.5 m1/100 gm/min) when compared with contralateral control white matter (24.8 ± 1.8 ml/100 gm/min). If the values for oedematous brain were corrected for dilution, however, the LCBF averaged 25.3 ± 1.7 ml/100 gm/min, which was the same as control.

LCMRgl was found to be significantly increased in plasma-infused white matter (16.3 ± 2.2 µmol/ 100 gm/min), compared with control white matter (10.7 ± 1.3). This difference remained despite correction for dilution and recalculation of LCMRgl values based on altered kinetic constants found in oedematous brain. A similar increase in LCMRgl was noted with saline infusion oedema.

It is concluded that increased tissue water does not alter CBF, but does induce an increase in anaerobic metabolism.


White Matter Cerebral Blood Flow Brain Oedema Vasogenic Oedema Local Cerebral Glucose Utilization 
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  1. 1.
    Blasberg RG, Gazendam J, Patlak CS, Fenstermacher JD (1980) Quantitative autoradiographic studies of brain oedema and a comparison of multo-isotope autoradiographic techniques. In: Cervos-navarro J, Ferszt R (eds) Brain oedema. Raven Press, New York, pp 255–270Google Scholar
  2. 2.
    Bothe HW, van der Kerckhoff W, Paschen W et al (1982) Dissociation between blood flow and metabolic disturbances in oedema associated with experimental abscess in cats. In: Go KG, Baethmann A (eds) Recent progress in study and therapy of oedema. Plenum Press, New York, pp 355–363Google Scholar
  3. 3.
    Bruce DA, Vapalahti M, Schutz H, Langfitt TW (1972) rCBF, CMRO2 and intracranial pressure following a local cold injury of the cortex. In: Brock M, Dietz H (eds) Intracranial pressure. Springer, Berlin Heidelberg, New York, pp 85–89CrossRefGoogle Scholar
  4. 4.
    Dick AR, Nelson SR, Turner PL (1980) Quantified regional cerebral glucose consumption, rCBF and oedema and the effects of papaverine in cats with cortical cold injury. In: Shulman K, Marmarou A, Miller JD et al (eds) Intracranial pressure IV. Springer, Berlin Heidelberg, New York, pp 261–267CrossRefGoogle Scholar
  5. 5.
    Fenske A (1973) Extracellular space and electrolyte distribution in cortex and white matter of dog brain in cold induced oedema. Acta Neurochir (Wien) 28: 81–94CrossRefGoogle Scholar
  6. 6.
    Ginsberg MD, Reivich M (1979) Use of the 2-deoxyglucose method of local cerebral glucose utilization in the abnormal brain: Evaluation of the lumped constant during ischaemia. Acta Neurol Scand 60 (72): 226–227Google Scholar
  7. 7.
    Lammertsma AA, Wise RJS, Jones T (1984) Regional cerebral blood flow and oxygen utilization in oedema associated with cerebral tumours. In: Go GK, Baethamnn A (eds) Recent progress in the study and therapy of brain oedema. Plenum Press, New York, pp 331–334Google Scholar
  8. 8.
    Lammertsma AA, Wise RJS, Cox TCS et al (1985) Measurement of blood flow, oxygen extraction ratio and fractional blood volume in human brain tumours and surrounding oedematous–brain. Br J Radiol 58: 725–734PubMedCrossRefGoogle Scholar
  9. 9.
    Marmarou A, Poll W, Shulman K, Bhagauaw H (1978) A simple gravimetric technique for measurement of cerebral oedema. J Neurosurg 49: 530–537PubMedCrossRefGoogle Scholar
  10. 10.
    Marmarou A, Takagi H, Walstra G, Shulman K (1980) The role of brain tissue pressure in autoregulation of CBF in areas of brain oedema. In: Shulman K, Marmarou A, Miller JD et al (eds) Intracranial pressure IV. Springer, Berlin Heidelberg New York, pp 257–260CrossRefGoogle Scholar
  11. 11.
    Marmarou A, Takagi H, Shulman K (1980) Biomechanics of brain oedema and effects on local blood flow. In: Cervos-Navarro S, Ferszt R (eds) Advances in Neurology, vol 28: Brain oedema. Raven Press, New York, pp 345–357Google Scholar
  12. 12.
    Marshall LF, Bruce DA, Graham DI, Langfitt TW (1976) Alterations in behavior brain electrical activity, cerebral blood flow, and intracranial pressure produced by triethlyl tin sulfate induced cerebral oedema. Stroke 7: 21–25PubMedCrossRefGoogle Scholar
  13. 13.
    Pappius HM, Savaki HE, Fieschi C et al (1979) Osmotic opening of the blood-brain barrier and local cerebral glucose utilization. Ann Neurol 5: 211–219PubMedCrossRefGoogle Scholar
  14. 14.
    Reivich M, Jehle J, Solokoff L, Kety SJ (1969) Measurement of regional cerebral blood flow with antipyrine-C’ in awake cats. J Appl Physiol 27: 296PubMedGoogle Scholar
  15. 15.
    Reulen HJ, Medzihradsky F, Enzenbach R et al (1969) Electrolytes, fluids, and energy metabolism in human cerebral oedema. Arch Neurol 21: 517–525PubMedCrossRefGoogle Scholar
  16. 16.
    Reulen HJ, Samii M, Fenske A et al (1971) Energy metabolism and electrolyte distribution in cold injury oedema. In: Head injuries. Churchill-Livingston, London, pp 232–239Google Scholar
  17. 17.
    Sakurada O, Kennedy C, Jehle J et al (1978) Measurement of local cerebral blood flow with iodo[14C] antipyrine. Am J Physiol 234: H59 - H66PubMedGoogle Scholar
  18. 18.
    Savaki HE, Davidsen L, Smith C, Sokoloff L (1980) Measurement of free glucose turnover in brain. J Neurochem 32: 495–502CrossRefGoogle Scholar
  19. 19.
    Schmiedek P et al (1974) Energy state and glycolysis in human cerebral oedema. J Neurosurg 40: 351–364CrossRefGoogle Scholar
  20. 20.
    Sokoloff L, Reivich M, Kennedy C, Des rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anaesthetized albino rat. J Neurochem 28: 897Google Scholar
  21. 21.
    Sokoloff L (1980) The [14C] deoxyglucose method for the quantative determination of local cerebral glucose utilization: theoretical and practical considerations. In: Passoneau JV et al (eds) Cerebral metabolis and neural function. Williams Wilkins, Baltimore, pp 319–330Google Scholar
  22. 22.
    Sokoloff L (1981) Localization of functional activity in the central nervous sytem by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1: 7–36PubMedCrossRefGoogle Scholar
  23. 23.
    Sutton LN, Barranco D, Greenberg J et al (1989) Cerebral blood flow and glucose metabolism in experimental brain oedema. J Neurosurg 71: 868–874PubMedCrossRefGoogle Scholar
  24. 24.
    Sutton LN, Bruce DA, Welsh FA, Jaggi J (1980) Metabolic and electrophysiologic consequences of vasogenic oedema. In: Cervos-Navarro J, Ferszt R (eds) Advances in neurology, vol 28: Brain oedema. Raven Press, New York, pp 241–254Google Scholar
  25. 25.
    Sutton LN, Welsh FA, Bruce DA (1980) Bioenergetics of acute vasogenic oedema. J Neurosurg 53 (4): 470–476PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. N. Sutton
    • 1
    • 2
  • J. Greenberg
    • 1
  • F. Welsh
    • 1
  1. 1.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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