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Blood Flow and Metabolism in Vasogenic Oedema

  • L. N. Sutton
  • J. Greenberg
  • F. Welsh
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

The relationship between white matter cerebral blood flow (CBF) and glucose metabolism (LCMRgl) was studied in a plasma infusion model of vasogenic oedema in cats. LCBF as determined by iodoantipyrine was found to be significantly decreased in oedematous white matter (17.3 ± 1.5 m1/100 gm/min) when compared with contralateral control white matter (24.8 ± 1.8 ml/100 gm/min). If the values for oedematous brain were corrected for dilution, however, the LCBF averaged 25.3 ± 1.7 ml/100 gm/min, which was the same as control.

LCMRgl was found to be significantly increased in plasma-infused white matter (16.3 ± 2.2 µmol/ 100 gm/min), compared with control white matter (10.7 ± 1.3). This difference remained despite correction for dilution and recalculation of LCMRgl values based on altered kinetic constants found in oedematous brain. A similar increase in LCMRgl was noted with saline infusion oedema.

It is concluded that increased tissue water does not alter CBF, but does induce an increase in anaerobic metabolism.

Keywords

White Matter Cerebral Blood Flow Brain Oedema Vasogenic Oedema Local Cerebral Glucose Utilization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. N. Sutton
    • 1
    • 2
  • J. Greenberg
    • 1
  • F. Welsh
    • 1
  1. 1.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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