Hemodynamic Effects of Decompressive Craniectomy in Cold Induced Brain Oedema
An experimental model of cold induced brain oedema was carried out in 7 albino rabbits by topic application of fluid N2 on the skull to examine the favourable effects of an appropriate tailored craniodural opening both on the whole brain perfusion and on the local dynamics of the oedematous fluid. After positioning the animals in a stereotactic frame the following parameters were recorded: ICP, carotid blood pressure and flow velocity, EEG, EKG. Histological staining with Evan’s blue was utilized to check fluid extravasation. In all the animals the lesion was followed both by an ICP increase and a reduction in the carotid blood flow velocity so indicating an increase in the cerebrovascular resistances. In 4 animals the removal of the craniodural flap over the lesion dramatically reduced the ICP values and normalized the blood flow velocity. No difference in the Evan’s blue distribution was noticed between the two groups of animals.
KeywordsBlood Flow Velocity Decompressive Craniectomy Brain Perfusion Albino Rabbit Stereotactic Frame
Unable to display preview. Download preview PDF.
- 1.Bruce DA, Vapalahti M, Schutz H, Langfitt TW (1972) rCBF, CMRO2 and intracranial pressure following a local cold injury of the cortex. In: Brock M, Dietz H (eds) Intracranial pressure I. Springer, Berlin Heidelberg New YorkGoogle Scholar
- 3.Meyer FB, Anderson RE, Sundt TM, Yaksh TL (1986) Intracellular brain pH, indicator tissue perfusion, EEG and histology in severe and moderate focal cortical ischaemia in the rabbit. J Cereb Blood Flow Metab 6: 71–78Google Scholar