Advertisement

Changes in Epidural Pulse Pressure in Brain Oedema Following Experimental Focal Ischaemia

  • M. Mase
  • H. Nagai
  • H. Mabe
  • K. Kamiya
  • T. Matsumoto
  • Y. Ueda
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

This study was carried out to clarify the changes of pulse pressure of the intracranial pressure pulse wave in ischaemic brain oedema. Intracranial pressure and PP were measured in two groups of anaesthetized dogs; 1) increased volume of cerebrospinal fluid by cisternal saline injection (control group), 2) brain oedema caused by focal ischaemia (oedema group). Ischaemia was induced by 2 hours of occlusion of the anterior, middle cerebral and internal carotid arteries. The canine focal ischaemic model showed consistent ischaemic damage in the caudate nucleus and produced brain oedema successfully. PP increased linearly with rising ICP to 35 mm Hg, and PP in the oedema group was significantly smaller than that in the control group at the same ICP value. The slopes of the regression equation of ICP and PP were significantly different between the oedema and control group (oedema: 0.057 ± 0.029, control: 0.106 ± 0.009), mean ± SD, P < 0.005).

These results suggest that PP is easily affected by ischaemic brain oedema, which indicates increase of the brain tissue in the cranium. We conclude that PP is affected even at the same ICP value when intracranial components have altered.

Keywords

Brain Oedema Cerebral Blood Volume Focal Ischaemia Triphenyl Tetrazolium Chloride Triphenyl Tetrazolium Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adolph RI, Fukusumi H. Fowler NO (1967) Origin of cerebrospinal fluid pulsations. Am J Physiol 222: 840–846Google Scholar
  2. 2.
    Aoyagi N, Masuzawa H, Sano K et al (1980) Compliance of the brain. Brain and Nerve 32: 47–56PubMedGoogle Scholar
  3. 3.
    Avezaat CJJ, van Eijndhoven JHM, Wyper DJ (1980) Effects of hypercapnia and arterial hypotension and hypertension on cerebrospinal fluid pulse pressure and intracranial volume-pressure relationships. J Neurol Neurosurg Psychiatry 42: 222–234CrossRefGoogle Scholar
  4. 4.
    Hirai O, Handa H, Ishikawa M (1982) Intracranial pressure pulse waveform: Considerations about its origin and methods of estimating intracranial pressure dynamics. Brain and Nerve 34: 1059–1065PubMedGoogle Scholar
  5. 5.
    Iannotti F, Hoff JT, Schielke GP (1985) Brain tissue pressure in focal cerebral ischaemia. J Neurosurg 62: 83–89PubMedCrossRefGoogle Scholar
  6. 6.
    Matsumoto T (1985) Influence of intracranial components on intracranial pressure pulse wave. Neurol Med Chir (Tokyo) 25: 411–417CrossRefGoogle Scholar
  7. 7.
    Matsumoto T, Nagai H, Kasuga Y et al (1986) Changes in intracranial pressure ( ICP) pulse wave following hydrocephalus. Acta Neurochir (Wien) 82: 50–56CrossRefGoogle Scholar
  8. 8.
    Ohno M (1986) Correlation between EEG, CBF, and ICP on experimental focal ischaemic brain produced by transorbital approach in dogs. Jpn J Stroke 8: 69–79CrossRefGoogle Scholar
  9. 9.
    Portnoy HD, Chopp M (1981) Cerebrospinal fluid pulse wave form analysis during hypercapnia and hypoxia. Neurosurgery 9: 14–27PubMedCrossRefGoogle Scholar
  10. 10.
    Szewczykowski J, Sliwka S, Kunicki A et al (1977) A fast method of estimating the elastance of the intracranial system. J Neurosurg 47: 19–26PubMedCrossRefGoogle Scholar
  11. 11.
    Tamura A, Asano T, Sano K (1980) Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion. Stroke 11: 487–493PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Mase
    • 2
  • H. Nagai
    • 1
  • H. Mabe
    • 1
  • K. Kamiya
    • 1
  • T. Matsumoto
    • 1
  • Y. Ueda
    • 1
  1. 1.Department of NeurosurgeryNagoya City University Medical SchoolNagoyaJapan
  2. 2.Department of NeurosurgeryNagoya City University Medical SchoolMizuho-cho, Mizuho-ku, Nagoya, 467Japan

Personalised recommendations