Experimental Studies for Use of Magnetic Resonance in Brain Water Measurements

  • P. Fatouros
  • A. Marmarou
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The accurate description and quantification of altered brain water resulting from different pathologic conditions is of critical clinical importance. In this work we determined the influence of total water content, hydration fraction and magnetic field strength on observed proton relaxation rates by means of in vitro and in vivo model studies and developed a scheme for determining water content at any field strength. Equations relating T1 relaxation times and brain water content are derived. This allows a non-invasive measure of brain water to be determined in the clinical setting.


Gelatin Solution Brain Water Content Total Water Content Longitudinal Relaxation Time Relaxation Time Measurement 
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  1. 1.
    MacDonald HL, Bell BA, Smith MA, Kean DM, Tocher JL, Douglas RHB, Miller JD, Best JJK (1986) Br. J. Radiol 59: 355PubMedCrossRefGoogle Scholar
  2. 2.
    Bell BA, Kean DM, MacDonald HL, Barnett GH, Douglas RHB, Smith MA, McGhee CNJ, Miller JD, Tocher JL, Best JJK (1987) Lancet is 66Google Scholar
  3. 3.
    Kaneoke Y, Furuse M, Inao S, Saso K, Yoshida K, Motegi Y, Mizuno M, and Izawa A (1987) Magn. Reson. Imaging 5: 415PubMedCrossRefGoogle Scholar
  4. 4.
    Marmarou A, Nakamura T, Tanaka K (1984) The kinetics of fluid movement through brain tissue. Seminars in Neurology, Vol 4, 439-444CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • P. Fatouros
    • 2
  • A. Marmarou
    • 1
  1. 1.Departments of Radiology and NeurosurgeryMedical College of VirginiaRichmondUSA
  2. 2.Radiation Physics DivisionMedical College of VirginiaRichmondUSA

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