Perifocal Brain Oedema in Experimental Brain Abscess in Rats

  • Y. Nakagawa
  • K. Shinno
  • K. Okajima
  • K. Matsumoto
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


An experimental cerebral abscess model in which staphylococcus aureus was inoculated into the brain parenchyma of rats was evaluated for perifocal brain oedema. Blood-brain barrier permeability was studied using various kinds of tracers; sodium fluorescein as a small molecule and Evans blue and HRP as macromolecular tracers. Brain abscess with clear delineation of fibrous capsule formation were found in all animals. Extravasation of tracers was demonstrated in the capsule (Evans blue), extracellular space (HRP) and white matter (sodium fluorescein). There were two types of oedema formation, so called vasogenic oedema and cytotoxic brain oedema.


White Matter Brain Oedema Brain Abscess Evans Blue Vasogenic Oedema 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Y. Nakagawa
    • 1
  • K. Shinno
    • 1
  • K. Okajima
    • 1
  • K. Matsumoto
    • 2
  1. 1.Department of NeurosurgeryKagawa National Children’s HospitalZentsuji city, KagawaJapan
  2. 2.Department of NeurosurgeryUniversity TokushimaJapan

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