Changes in Free Water Content and Energy Metabolism of the Brain in Experimental Hydrocephalus

  • N. Tamaki
  • T. Nagashima
  • K. Ehara
  • M. Kimura
  • S. Matsumoto
  • N. Iriguchi
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


In acute and subacute hydrocephalus periventricular oedema is most prominent. At these stages of hydrocephalus, the free water content is increased and the bound water content, to the contrary, significantly decreased in the periventricular white matter. The bioenergetic state is also altered. In the chronic stage the ratio of free-to-bound water content returns to a level near the control value, leading to a decrease of periventricular oedema by formation of alternative pathways of CSF absorption. The bioenergetic state was slightly altered at this stage.


Chronic Stage Periventricular White Matter Cortical Gray Matter Total Water Content Acute Hydrocephalus 
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  1. 1.
    Bradbury MWB, Cserr HF, Westrop RJ (1981) Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit. Am J Physiol 240: F329 — F336PubMedGoogle Scholar
  2. 2.
    Del Bigio MR, Bruni JE (1987) Cerebral water content in silicone oil-induced hydrocephalic rabbits. Pediatr Neurosci 13: 72–77PubMedCrossRefGoogle Scholar
  3. 3.
    Drake JM, Potts DG, Lemaire C (1989) Magnetic resonance imaging of Silastic-induced canine hydrocephalus. Surg Neurol 31: 28–40PubMedCrossRefGoogle Scholar
  4. 4.
    Erlich SS, McComb JG, Hyman S et al (1986) Ultrastructural morphology of the olfactory pathway for cerebrospinal fluid drainage in the rabbit. J Neurosurg 64: 466–473PubMedCrossRefGoogle Scholar
  5. 5.
    Fishman RA, Greer M (1963) Experimental obstructive hydro- cephalus. Changes in the cerebrum. Arch Neurol 8: 156–161PubMedCrossRefGoogle Scholar
  6. 6.
    Furuse M, Gonda T, Inao S et al (1987) Thermal analysis on water components in brain tissue-quantitative determination of free and bound water fractions. Brain Nerve 39: 761–767PubMedGoogle Scholar
  7. 7.
    Higashi K, Asahisa H, Ueda N et al (1986) Cerebral blood flow and metabolism in experimental hydrocephalus. Neurol Res 8: 169–176PubMedGoogle Scholar
  8. 8.
    Kuntz ID, Zipp A (1977) Water in biological systems. N Engl J Med 297: 262–266PubMedCrossRefGoogle Scholar
  9. 9.
    Lux WE Jr, Hochwald GM, Sahar A et al (1970) Periventricular water content. Effect of pressure in experimental chronic hydrocephalus. Arch Neurol 23: 475–479PubMedCrossRefGoogle Scholar
  10. 10.
    McLone DG, Bondareff W, Raimondi AJ (1971) Brain edema in the hydrocephalic by-3 mouse: submicroscopic morphology. J Neuropathol Exp Neurol 30: 627–637PubMedCrossRefGoogle Scholar
  11. 11.
    Ogata J, Hochwald GM, Cravioto H et al (1972) Light and electron microscopic studies of experimental hydrocephalus. Ependymal and subependymal areas. Acta Neuropathol (Berl) 21: 213–223PubMedCrossRefGoogle Scholar
  12. 12.
    Rosenberg CA, Saland L, Kyner WT (1983) Pathophysiology of periventricular tissue changes with raised CSF pressure in cats. J Neurosurg 59: 606–611PubMedCrossRefGoogle Scholar
  13. 13.
    Rubin RC, Hochwald GM, Tiell M et al (1976) Hydrocephalus. I. Histological and ultrastructural changes in the preshunted cortical mantle. Surg Neurol 5: 109–114PubMedGoogle Scholar
  14. 14.
    Rubin RC, Hochwald GM, Tiell M et al (1976) Hydrocephalus. II. Cell number and size, and myelin content of the preshunted cerebral cortical mantle. Surg Neurol 5: 115–118PubMedGoogle Scholar
  15. 15.
    Weller RO, Mitchel J (1980) Cerebrospinal fluid edema and its sequelae in hydrocephaly. Adv Neurol 28: 111–123PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • N. Tamaki
    • 2
  • T. Nagashima
    • 1
  • K. Ehara
    • 1
  • M. Kimura
    • 1
  • S. Matsumoto
    • 1
  • N. Iriguchi
    • 1
  1. 1.Department of Neurosurgery, System Engineering LaboratoryKobe University School of Medicine, Kobe and Asahi Chemical Industry Inc.AtsugiJapan
  2. 2.Department of NeurosurgeryKobe University School of Medicine5-1, Kusunoki-cho 7chome, Chuo-ku, Kobe 650Japan

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