Hydrocephalic Oedema in Normal-Pressure Hydrocephalus

  • N. Tamaki
  • T. Nagashima
  • K. Ehara
  • T. Shirakuni
  • S. Matsumoto
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The hydrocephalic oedema in normal-pressure hydrocephalus (NPH) was evaluated by measurement of the relaxation time of protons of the water molecules of brain tissue. Patients with NPH were divided into two groups: shunt responders and shunt non-responders. In the group of shunt responders both T1 and T2 of periventricular white matter were significantly prolonged compared to those of controls, and shortened after shunting. Both T1 and T2 of white matter were significantly longer than of gray matter, while a reversed relationship was seen in normal controls. However, in the group of shunt non-responders, T1 of white matter was significantly prolonged, while T2 of the same area not. There was no change in either T1 or T2 of this region after shunting. Both T1 and T2 were almost the same in white and gray matter in shunt non-responders. It is suggested that periventricular abnormalities seen in various diseases may be distinguished on the basis of the relaxation behavior of protons of tissue water.


White Matter Gray Matter Periventricular White Matter Nuclear Magnetic Resonance Imaging Ventricular Shunting 
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  1. 1.
    Barnes D, McDonald WI, Jonson G et al (1987) Quantitative nuclear magnetic resonance imaging: Characterization of experimental cerebral oedema. J Neurol Neurosurg Psychiatry 50: 125–133Google Scholar
  2. 2.
    Bederson JB, Bartkowski HM, Moon K et al (1984) Nuclear magnetic resonance imaging and spectroscopy in experimental brain edema in a rat model. J Neurosurg 64: 795–802Google Scholar
  3. 3.
    Belton PS, Packer KJ (1974) Pulsed NMR studies of water in striated muscle. III. The effects of water content. Biochim Biophys Acta 354: 307–314CrossRefGoogle Scholar
  4. 4.
    Bottomley PA, Hardy CJ, Argersinger RE et al (1987) A review of H-1 nuclear magnetic resonance relaxation in pathology: Are Ti and T2 diagnostic? Med Phys 14: 1–37PubMedCrossRefGoogle Scholar
  5. 5.
    Bradley WG Jr, Waluch V, Brant-Zawadzki M etal (1984) Patchy, periventricular white matter lesions in the elderly: A common observation during NMR imaging. Noninvasive Med Imag 1: 35–41Google Scholar
  6. 6.
    Cooke R, Kuntz ID (1974) The properties of water in biological systems. Ann Rev Biophys Bioeng 3: 95–126CrossRefGoogle Scholar
  7. 7.
    Furuse M, Gonda T, Inao S et al (1987) Thermal analysis on water compounds in brain tissue. Quantitative determination of free and bound water fractions. Brain Nerve (Tokyo) 39: 761–767PubMedGoogle Scholar
  8. 8.
    George AE, de Leon MJ, Kalnin A et al (1986) Leucoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies. AJNR 7: 567–570Google Scholar
  9. 9.
    Gerard G, Weisberg LA (1986) Magnetic resonance imaging in adult white matter disorders and hydrocephalus. Semin Neurol 6: 17–27PubMedCrossRefGoogle Scholar
  10. 10.
    Go KG, Edzes HT (1975) Water in brain edema. Observations by the pulsed nuclear magnetic resonance technique. Arch Neurol 32: 462–465CrossRefGoogle Scholar
  11. 11.
    Hansen JR (1971) Pulsed NMR study of water mobility in muscle and brain tissue. Biochim Biophys Acta 230: 482–486PubMedCrossRefGoogle Scholar
  12. 12.
    Kertesz A, Black SE, Tokar G et al (1988) Periventricular and subcortical hyperintensities on magnetic resonance imaging. `Rims, caps, and unidentified bright objects’. Arch Neurol 45: 404–408PubMedCrossRefGoogle Scholar
  13. 13.
    Pollay M, Curi F (1967) Secretion of cerebrospinal fluid by ventricular ependyma of the rabbit. Am J Physio,1213: 1031–1038Google Scholar
  14. 14.
    Saryan LA, Hollis DP, Economou JS et al (1974) Brief communication: Nuclear magnetic resonance studies of cancer. IV. Correlation of water content with tissue relaxation times. J Natl Cancer Inst 52: 599–602PubMedGoogle Scholar
  15. 15.
    Sze G, De Armond SJ, Brant-Zawadzki M etal (1986) Foci of MRI signal ( Pseudo lesions) anterior to the frontal horns: Histologic correlation of a normal finding. AJNR 7: 381–387Google Scholar
  16. 16.
    Tamaki N, Yamashita H, Kimura M et al (1990) Changes in the components and content of biological water in the brain in experimental rabbit hydrocephalus. J Neurosurg (in press)Google Scholar
  17. 17.
    Zimmerman RD, Fleming CA, Lee BCP et al (1986) Periventricular hyperintensity as seen by magnetic resonance. Prevalence and significance. AJNR 7: 13–20Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • N. Tamaki
    • 1
  • T. Nagashima
    • 1
  • K. Ehara
    • 1
  • T. Shirakuni
    • 1
  • S. Matsumoto
    • 1
  1. 1.Department of NeurosurgeryKobe University School of MedicineKobeJapan

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