Skip to main content
SpringerLink
Log in

Glutamine Synthetase Inhibition Prevents Cerebral Oedema During Hyperammonemia

  • Conference paper
Brain Edema VIII

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

  • 181 Accesses

Summary

The relationship between cerebral oedema and cerebral glutamine accumulation was investigated during acute hyperammonemia in anesthetized rats. Six hours of ammonium acetate infusion resulted in an increase in cortical glutamine concentration and a decrease in specific gravity. Pretreatment with methionine sulfoximine inhibited glutamine synthetase, prevented the increase in glutamine during hyperammonemia, and prevented the decrease in specific gravity. We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Brusilow SW, Batshaw ML, Waber L (1982) Neonatal hyperammonemic coma. Adv Pediatr 29: 69–103

    PubMed  CAS  Google Scholar 

  2. Brusilow SW, Traystman RJ (1986) Letter to the Editor. N Engl J Med 314: 786

    PubMed  CAS  Google Scholar 

  3. Butterworth RF, Giguere JF, Michaud J, Lavoie J, Layrargues GP (1987) Ammonia: key factor in the pathogenesis of hepatic encephalopathy. Neurochem Pathol 6: 1–12

    Article  PubMed  CAS  Google Scholar 

  4. Cooper AJL, Plum F (1987) Biochemistry and physiology of brain ammonia. Physiol Rev 67: 440–519

    PubMed  CAS  Google Scholar 

  5. Marmarou A, Poll W, Shulman K, Bhagavan H (1978) A simple gravimetric technique for measurement of cerebral edema. J Neurosurg 49: 530–537

    Article  PubMed  CAS  Google Scholar 

  6. Norenberg MD, Martinez-Hernandez A (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 161: 303–310

    Article  PubMed  CAS  Google Scholar 

  7. Pilbeam CM, McD Anderson R, Bhathal PS (1983) The brain in experimental portal-systemic encephalopathy. II. Water and electrolyte changes. J Pathol 140: 347–355

    Article  PubMed  CAS  Google Scholar 

  8. Rao SLN, Meister A (1972) In vivo formation of methionine sulfoximine phosphate, a protein bound metabolite of methonine sulfoximine. Biochemistry 11: 1123–1127

    Article  PubMed  CAS  Google Scholar 

  9. Shaywitz AB, Rothstein P, Venes JL (1980) Monitoring and management of increased intracranial pressure in Reye syndrome: Result in 29 children. Pediatrics 66: 198–204

    PubMed  CAS  Google Scholar 

  10. Zimmerman S, Bachman C, Columbo J (1981) Ultrastructural pathology in congenital defects of the urea cycle: ornithine transcarbamylase and carbamyl phosphate synthetase deficiency. Virchows Arch [A] 393: 321–331

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology/Critical Care Medicine, and Pediatrics, The Johns Hopkins Medical Institution, Baltimore, Maryland, USA

    H. Takahashi, S. W. Brusilow & R. J. Traystman

  2. Department of Anesthesiology & Critical Care Medicine, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD, 21205, USA

    Dr. R. C. Koehler

Authors
  1. H. Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. R. C. Koehler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. W. Brusilow
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. J. Traystman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag

About this paper

Cite this paper

Takahashi, H., Koehler, R.C., Brusilow, S.W., Traystman, R.J. (1990). Glutamine Synthetase Inhibition Prevents Cerebral Oedema During Hyperammonemia. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_117

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_117

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation