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Cerebrovascular Permeability in Acute Hypertension: Effect of Flunarizine

  • Conference paper
Book cover Brain Edema VIII

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

Summary

The pattern of Evans blue extravasation in the brain in norepinephrine-induced acute hypertension is similar to our previous observations using horseradish peroxidase as a tracer. Pretreatment with flunarizine IV resulted in significant reduction of RISA leakage in all regions of the brains of acutely hypertensive rats. The reduction in RISA leakage in the drug-treated hypertensive group is not attributable to differences in the blood pressure elevations which were not significantly different in both groups. These studies suggest a role for calcium in the increased endothelial permeability occurring in cerebral vessels in acute hypertension. Further morphological studies are required to determine whether flunarizine reduces permeability by decreasing pinocytosis.

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References

  1. Nag S (1988) Localisation of calcium-activated adenosine-triphosphatase (Ca2+-ATPase) in intracerebral arterioles in acute hypertension. Acta Neuropathol (Berl) 75: 547–553

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  2. Nag S (1990) Ultracytochemical localisation ofNa+, K+-ATPase in cerebral endothelium in acute hypertension. Acta Neuropathol (Berl) in press

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  3. Nag S, Harik SI (1987) Cerebrovascular permeability to horseradish peroxidase in hypertensive rats: effects of unilateral locus ceruleus lesion. Acta Neuropathol (Berl) 73: 247–253

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Author information

Authors and Affiliations

  1. Department of Pathology (Neuropathology) and Kingston General Hospital, Queen’s University, Kingston, Ontario, Canada, K7L 3N6

    S. Nag

  2. Department of Pathology (Neuropathology) and Kingston General Hospital, Queen’s University, Kingston, Ontario, Canada

    L. Young

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  1. S. Nag
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  2. L. Young
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

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© 1990 Springer-Verlag

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Nag, S., Young, L. (1990). Cerebrovascular Permeability in Acute Hypertension: Effect of Flunarizine. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_116

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  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_116

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

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