Cerebrovascular Permeability in Acute Hypertension: Effect of Flunarizine

  • S. Nag
  • L. Young
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The pattern of Evans blue extravasation in the brain in norepinephrine-induced acute hypertension is similar to our previous observations using horseradish peroxidase as a tracer. Pretreatment with flunarizine IV resulted in significant reduction of RISA leakage in all regions of the brains of acutely hypertensive rats. The reduction in RISA leakage in the drug-treated hypertensive group is not attributable to differences in the blood pressure elevations which were not significantly different in both groups. These studies suggest a role for calcium in the increased endothelial permeability occurring in cerebral vessels in acute hypertension. Further morphological studies are required to determine whether flunarizine reduces permeability by decreasing pinocytosis.


Occipital Lobe Evans Blue Hypertensive Group Calcium Entry Blocker Acute Hypertension 
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  1. 1.
    Nag S (1988) Localisation of calcium-activated adenosine-triphosphatase (Ca2+-ATPase) in intracerebral arterioles in acute hypertension. Acta Neuropathol (Berl) 75: 547–553CrossRefGoogle Scholar
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    Nag S (1990) Ultracytochemical localisation ofNa+, K+-ATPase in cerebral endothelium in acute hypertension. Acta Neuropathol (Berl) in pressGoogle Scholar
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    Nag S, Harik SI (1987) Cerebrovascular permeability to horseradish peroxidase in hypertensive rats: effects of unilateral locus ceruleus lesion. Acta Neuropathol (Berl) 73: 247–253CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Nag
    • 1
  • L. Young
    • 2
  1. 1.Department of Pathology (Neuropathology) and Kingston General HospitalQueen’s UniversityKingstonCanada
  2. 2.Department of Pathology (Neuropathology) and Kingston General HospitalQueen’s UniversityKingstonCanada

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