Effect of L-arginine on Haemoglobin-induced Inhibition of Endothelium-dependent Relaxation of Isolated Cerebral Arteries

  • L. Schilling
  • A. A. Parsons
  • J. R. L. Mackert
  • M. Wahl
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)


The effects of Oxy-haemoglobin were investigated in the rat isolated basilar artery and compared to Methylene blue and NG-Nitro-L-Arginine (NOLAG), as these compounds interfere with the relaxation induced by the endothelium-derived relaxing factor. Acetylcholine induced a concentration-related relaxation of serotonin-precontracted arteries which was further enhanced by the application of L-arginine. Similarly, the spasmolytic activity of L-arginine was enhanced by acetylcholine. Oxy-haemoglobin, Methylene blue and NOLAG induced an increase of resting tension and inhibited acetylcholine-induced relaxation. Furthermore, inhibition of acetylcholine-induced relaxation by Oxy-haemoglobin and NOLAG but not that by Methylene blue was partially reversed by L-arginine.


Nitric Oxide Methylene Blue Basilar Artery Cerebral Vasospasm Soluble Guanylate Cyclase 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. Schilling
    • 1
  • A. A. Parsons
    • 1
  • J. R. L. Mackert
    • 1
  • M. Wahl
    • 1
  1. 1.Department of PhysiologyUniversity of MunichFederal Republic of Germany

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