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Effect of L-arginine on Haemoglobin-induced Inhibition of Endothelium-dependent Relaxation of Isolated Cerebral Arteries

  • L. Schilling
  • A. A. Parsons
  • J. R. L. Mackert
  • M. Wahl
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

The effects of Oxy-haemoglobin were investigated in the rat isolated basilar artery and compared to Methylene blue and NG-Nitro-L-Arginine (NOLAG), as these compounds interfere with the relaxation induced by the endothelium-derived relaxing factor. Acetylcholine induced a concentration-related relaxation of serotonin-precontracted arteries which was further enhanced by the application of L-arginine. Similarly, the spasmolytic activity of L-arginine was enhanced by acetylcholine. Oxy-haemoglobin, Methylene blue and NOLAG induced an increase of resting tension and inhibited acetylcholine-induced relaxation. Furthermore, inhibition of acetylcholine-induced relaxation by Oxy-haemoglobin and NOLAG but not that by Methylene blue was partially reversed by L-arginine.

Keywords

Nitric Oxide Methylene Blue Basilar Artery Cerebral Vasospasm Soluble Guanylate Cyclase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. Schilling
    • 1
  • A. A. Parsons
    • 1
  • J. R. L. Mackert
    • 1
  • M. Wahl
    • 1
  1. 1.Department of PhysiologyUniversity of MunichFederal Republic of Germany

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