Advertisement

Immuno-fluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of monoamine oxidase A and monoamine oxidase B: a pilot study

  • G. Moll
  • R. Moll
  • P. Riederer
  • W. Gsell
  • H. Heinsen
  • R. M. Denney
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

Immunofluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of MAO-A and MAO-B revealed that only about 10% of the melanin-containing neurons are positive for MAO-A, while they are substantially free of MAO-B.

Keywords

Substantia Nigra Monoamine Oxidase Lower Picture Human Substantia Nigra Pigment Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Denney RM, Patel NT, Fritz RR, Abell CW (1982) A monclonal antibody elicited to human platelet monoamine oxidase. Isolation and specifity for human monoamine oxidase-B but not for A. Mol Pharmacol 22:500–508.Google Scholar
  2. Kochersperger LN, Waguespack A, Patterson JC, Hseih CCW, Weyler W, Salach JI, Denney RM (1985) Immunological uniqueness of human monoamine oxidase A and B. New evidence from studies with monoclonal antibodies to human MAO A. J Neurosci 11:2874–2881.Google Scholar
  3. Konradi C, Svoma E, Jellinger K, Riederer P, Denney R, Thibault J (1988) Topographic immunocytochemical mapping of monoamine oxidase-A, monoamine oxidase-B and tyrosine hydroxylase in human post mortem brain stem. Neuroscience 26:791–802.PubMedCrossRefGoogle Scholar
  4. Riederer P, Konradi C, Schay V, Kienzl E, Birkmayer G, Danielczyk W, Sofic E, Youdim MBH (1986) Localization of MAO-A and MAO-B in human brain: a step in understanding the therapeutic action of 1-deprenyl. Adv Neurol 46:111–118.Google Scholar
  5. Westlund KN, Denney RM, Rose RM, Abell CW (1988) Localization of distinct monoamine oxidase-A and monoamine oxidase-B cell populations in human brain stem. Neuroscience 25:439–456.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • G. Moll
    • 1
  • R. Moll
    • 2
  • P. Riederer
    • 1
  • W. Gsell
    • 1
  • H. Heinsen
    • 3
  • R. M. Denney
    • 4
  1. 1.Clinical Neurochemistry, Department of PsychiatryUniversity of WürzburgWürzburgFederal Republic of Germany
  2. 2.Institute of PathologyUniversity of MainzFederal Republic of Germany
  3. 3.Morphological Brain Research, Department of PsychiatryUniversity of WürzburgFederal Republic of Germany
  4. 4.Department of Human Biology and ChemistryUniversity of TexasGalvestonUSA

Personalised recommendations